TRI67

Details:

UniProt Entry: Q6ZTA4
Gene: TRIM67
Class: RING
Family: RING8
Protein length: 783
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7qs5

Protein Sequence ▾

>Q6ZTA4
MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG
AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK
SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR
LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP
SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF
PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD
KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL
KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE
PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT
HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV
VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY
DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG
VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL
SGN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	60	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
7	35	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
7	162	Domain	Zinc finger, RING-type	IPR001841	SM00184
22	31	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
203	253	Domain	B-box-type zinc finger	IPR000315	SM00336
210	253	Domain	B-box-type zinc finger	IPR000315	PS50119
298	340	Domain	B-box-type zinc finger	IPR000315	SM00336
298	340	Domain	B-box-type zinc finger	IPR000315	PS50119
300	340	Domain	B-box-type zinc finger	IPR000315	PF00643
347	473	Domain	B-box, C-terminal	IPR003649	SM00502
448	506	Domain	COS domain	IPR017903	PS51262
507	607	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
512	605	Homologous_superfamily	Fibronectin type III superfamily	IPR036116	SSF49265
513	607	Domain	Fibronectin type III	IPR003961	PS50853
513	594	Domain	Fibronectin type III	IPR003961	SM00060
521	597	Domain	Fibronectin type III	IPR003961	PF00041
528	604	Domain	Fibronectin type III	IPR003961	cd00063
576	772	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
589	780	Domain	B30.2/SPRY domain	IPR001870	PS50188
612	767	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
648	769	Domain	SPRY domain	IPR003877	SM00449
651	768	Domain	SPRY domain	IPR003877	PF00622

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010976	positive regulation of neuron projection development	Biological Process	IEA	GO_REF:0000107
GO:0046580	negative regulation of Ras protein signal transduction	Biological Process	IEA	GO_REF:0000107
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0032880	regulation of protein localization	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.