ZBT49

Details:

UniProt Entry: Q6ZSB9
Gene: ZBTB49
Class: RING
Family: RING6
Protein length: 765
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q6ZSB9
MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF RSLFQNSSSQ
KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT AQCLQVQNVL SLCHTFLKSA
TVVQPPGMPC NSTLSLQSTL TPDATCVISE NYPPHLLQEC SADAQQNKTL DESHPHASPS
VNRHHSAGEI SKQAPDTSDG SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP
FAFSTSTDLT TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ
MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS QSAEEKESEE
VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC GKPFKHPSNL ELHKRSHTGE
KPFECNICGK HFSQAGNLQT HLRRHSGEKP YICEICGKRF AASGDVQRHI IIHSGEKPHL
CDICGRGFSN FSNLKEHKKT HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC
GKCFGGSGDL RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS
QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG SYCKLRSMIQ
PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG GEPLQADGMA MIRSSLAALD
NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW GLAMKTLQNE NELDQ

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
3	128	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
5	119	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
15	119	Domain	BTB/POZ domain	IPR000210	PF00651
25	91	Domain	BTB/POZ domain	IPR000210	PS50097
25	121	Domain	BTB/POZ domain	IPR000210	SM00225
393	445	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
395	417	Domain	Zinc finger C2H2-type	IPR013087	SM00355
395	417	Domain	Zinc finger C2H2-type	IPR013087	PF00096
395	422	Domain	Zinc finger C2H2-type	IPR013087	PS50157
397	417	Domain	Zinc finger C2H2-type	IPR013087	PS00028
423	450	Domain	Zinc finger C2H2-type	IPR013087	PS50157
423	445	Domain	Zinc finger C2H2-type	IPR013087	SM00355
423	445	Domain	Zinc finger C2H2-type	IPR013087	PF00096
425	445	Domain	Zinc finger C2H2-type	IPR013087	PS00028
432	488	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
451	473	Domain	Zinc finger C2H2-type	IPR013087	PF00096
451	473	Domain	Zinc finger C2H2-type	IPR013087	SM00355
451	478	Domain	Zinc finger C2H2-type	IPR013087	PS50157
453	473	Domain	Zinc finger C2H2-type	IPR013087	PS00028
479	501	Domain	Zinc finger C2H2-type	IPR013087	SM00355
479	506	Domain	Zinc finger C2H2-type	IPR013087	PS50157
481	501	Domain	Zinc finger C2H2-type	IPR013087	PS00028
488	544	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
507	529	Domain	Zinc finger C2H2-type	IPR013087	SM00355
507	534	Domain	Zinc finger C2H2-type	IPR013087	PS50157
509	529	Domain	Zinc finger C2H2-type	IPR013087	PS00028
529	581	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
535	557	Domain	Zinc finger C2H2-type	IPR013087	SM00355
535	562	Domain	Zinc finger C2H2-type	IPR013087	PS50157
535	557	Domain	Zinc finger C2H2-type	IPR013087	PF00096
537	557	Domain	Zinc finger C2H2-type	IPR013087	PS00028
563	585	Domain	Zinc finger C2H2-type	IPR013087	PF00096
563	585	Domain	Zinc finger C2H2-type	IPR013087	PS50157
563	585	Domain	Zinc finger C2H2-type	IPR013087	SM00355
565	585	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000117
GO:0006221	pyrimidine nucleotide biosynthetic process	Biological Process	IEA	GO_REF:0000043
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0008285	negative regulation of cell population proliferation	Biological Process	IDA	PMID:25245946
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:25245946
GO:0051726	regulation of cell cycle	Biological Process	IDA	PMID:25245946
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001223	transcription coactivator binding	Molecular Function	IPI	PMID:25245946
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA	PMID:25245946
GO:0140297	DNA-binding transcription factor binding	Molecular Function	IDA	PMID:25245946

Enzyme–Substrate Interactions ▾

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