RN19B

Details:

UniProt Entry: Q6ZMZ0
Gene: RNF19B
Class: RBR
Family: RBR
Protein length: 732
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q6ZMZ0
MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTLHSVFS ASARGRRARA KPQAEPPPPA
AQPPPAPAPA AAQGPPPEAL PAEPAAEAEA EAAAAAAEPG FDDEEAAEGG GPGAEEVECP
LCLVRLPPER APRLLSCPHR SCRDCLRHYL RLEISESRVP ISCPECSERL NPHDIRLLLA
DPPLMHKYEE FMLRRYLASD PDCRWCPAPD CGYAVIAYGC ASCPKLTCER EGCQTEFCYH
CKQIWHPNQT CDMARQQRAQ TLRVRTKHTS GLSYGQESGP ADDIKPCPRC SAYIIKMNDG
SCNHMTCAVC GCEFCWLCMK EISDLHYLSP SGCTFWGKKP WSRKKKILWQ LGTLIGAPVG
ISLIAGIAIP AMVIGIPVYV GRKIHSRYEG RKTSKHKRNL AITGGVTLSV IASPVIAAVS
VGIGVPIMLA YVYGVVPISL CRGGGCGVST ANGKGVKIEF DEDDGPITVA DAWRALKNPS
IGESSIEGLT SVLSTSGSPT DGLSVMQGPY SETASFAALS GGTLSGGILS SGKGKYSRLE
VQADVQKEIF PKDTASLGAI SDNASTRAMA GSIISSYNPQ DRECNNMEIQ VDIEAKPSHY
QLVSGSSTED SLHVHAQMAE NEEEGSGGGG SEEDPPCRHQ SCEQKDCLAS KPWDISLAQP
ESIRSDLESS DAQSDDVPDI TSDECGSPRS HTAACPSTPR AQGAPSPSAH MNLSALAEGQ
TVLKPEGGEA RV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
67	400	Family	E3 ubiquitin ligase RBR family	IPR031127	PTHR11685
113	199	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
115	337	Domain	TRIAD supradomain	IPR044066	PS51873
119	167	Domain	Zinc finger, RING-type	IPR001841	PS50089
119	166	Domain	Zinc finger, RING-type	IPR001841	SM00184
186	251	Domain	IBR domain	IPR002867	SM00647
187	251	Domain	IBR domain	IPR002867	PF01485
254	333	Domain	IBR domain	IPR002867	SM00647
282	326	Domain	IBR domain	IPR002867	PF01485

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0042267	natural killer cell mediated cytotoxicity	Biological Process	IEA	GO_REF:0000107
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000043
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:27485036
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0044194	cytolytic granule	Cellular Component	IBA	GO_REF:0000033
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:16709802
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IBA	GO_REF:0000033
GO:0043130	ubiquitin binding	Molecular Function	IDA	PMID:27485036
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


Q9NWZ5	UCKL1	Yes	Yes	Yes	No	16709802	EBI-2466681	E3-specific

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.