TRI72

Details:

UniProt Entry: Q6ZMU5
Gene: TRIM72
Class: RING
Family: RING5
Protein length: 477
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 3kb5, 7y4s

Protein Sequence ▾

>Q6ZMU5
MSAAPGLLHQ ELSCPLCLQL FDAPVTAECG HSFCRACLGR VAGEPAADGT VLCPCCQAPT
RPQALSTNLQ LARLVEGLAQ VPQGHCEEHL DPLSIYCEQD RALVCGVCAS LGSHRGHRLL
PAAEAHARLK TQLPQQKLQL QEACMRKEKS VAVLEHQLVE VEETVRQFRG AVGEQLGKMR
VFLAALEGSL DREAERVRGE AGVALRRELG SLNSYLEQLR QMEKVLEEVA DKPQTEFLMK
YCLVTSRLQK ILAESPPPAR LDIQLPIISD DFKFQVWRKM FRALMPALEE LTFDPSSAHP
SLVVSSSGRR VECSEQKAPP AGEDPRQFDK AVAVVAHQQL SEGEHYWEVD VGDKPRWALG
VIAAEAPRRG RLHAVPSQGL WLLGLREGKI LEAHVEAKEP RALRSPERRP TRIGLYLSFG
DGVLSFYDAS DADALVPLFA FHERLPRPVY PFFDVCWHDK GKNAQPLLLV GPEGAEA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
6	76	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
14	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
14	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
14	54	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
29	38	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
81	122	Domain	B-box-type zinc finger	IPR000315	SM00336
81	122	Domain	B-box-type zinc finger	IPR000315	PS50119
83	121	Domain	B-box-type zinc finger	IPR000315	PF00643
271	475	Domain	B30.2/SPRY domain	IPR001870	PS50188
278	470	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
281	470	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
287	304	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
288	341	Domain	SPRY-associated	IPR006574	SM00589
291	339	Domain	SPRY-associated	IPR006574	PF13765
327	351	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
342	473	Domain	SPRY domain	IPR003877	SM00449
345	455	Domain	SPRY domain	IPR003877	PF00622
357	370	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
404	428	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010832	negative regulation of myotube differentiation	Biological Process	IEA	GO_REF:0000107
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0001778	plasma membrane repair	Biological Process	ISS	GO_REF:0000024
GO:0003012	muscle system process	Biological Process	ISS	GO_REF:0000024
GO:0006887	exocytosis	Biological Process	IEA	GO_REF:0000043
GO:0007517	muscle organ development	Biological Process	ISS	GO_REF:0000024
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051260	protein homooligomerization	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0042383	sarcolemma	Cellular Component	IBA	GO_REF:0000033
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	ISS	GO_REF:0000024
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0001786	phosphatidylserine binding	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0031435	mitogen-activated protein kinase kinase kinase binding	Molecular Function	IEA	GO_REF:0000107
GO:0031624	ubiquitin conjugating enzyme binding	Molecular Function	IEA	GO_REF:0000107
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾

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