LRSM1

Details:

UniProt Entry: Q6UWE0
Gene: LRSAM1
Class: RING
Family: RING9
Protein length: 723
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q6UWE0
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPFGAFA TCKVLQKKVL
IVHTNHLTSL LPKSCSLLSL ATIKVLDLHD NQLTALPDDL GQLTALQVLN VERNQLMQLP
RSIGNLTQLQ TLNVKDNKLK ELPDTVGELR SLRTLNISGN EIQRLPQMLA HVRTLEMLSL
DASAMVYPPR EVCGAGTAAI LQFLCKESGL EYYPPSQYLL PILEQDGIEN SRDSPDGPTD
RFSREELEWQ NRFSDYEKRK EQKMLEKLEF ERRLELGQRE HTQLLQQSSS QKDEILQTVK
EEQSRLEQGL SEHQRHLNAE RQRLQEQLKQ TEQNISSRIQ KLLQDNQRQK KSSEILKSLE
NERIRMEQLM SITQEETESL RRRDVASAMQ QMLTESCKNR LIQMAYESQR QNLVQQACSS
MAEMDERFQQ ILSWQQMDQN KAISQILQES AMQKAAFEAL QVKKDLMHRQ IRSQIKLIET
ELLQLTQLEL KRKSLDTESL QEMISEQRWA LSSLLQQLLK EKQQREEELR EILTELEAKS
ETRQENYWLI QYQRLLNQKP LSLKLQEEGM ERQLVALLEE LSAEHYLPIF AHHRLSLDLL
SQMSPGDLAK VGVSEAGLQH EILRRVQELL DAARIQPELK PPMGEVVTPT APQEPPESVR
PSAPPAELEV QASECVVCLE REAQMIFLNC GHVCCCQQCC QPLRTCPLCR QDIAQRLRIY
HSS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
32	209	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
80	102	Repeat	Leucine-rich repeat, typical subtype	IPR003591	SM00369
103	125	Repeat	Leucine-rich repeat, typical subtype	IPR003591	SM00369
126	147	Repeat	Leucine-rich repeat, typical subtype	IPR003591	SM00369
128	181	Repeat	Leucine-rich repeat	IPR001611	PF13855
149	171	Repeat	Leucine-rich repeat, typical subtype	IPR003591	SM00369
151	172	Repeat	Leucine-rich repeat	IPR001611	PS51450
563	633	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	IPR013761	G3DSA:1.10.150.50
566	632	Domain	Sterile alpha motif domain	IPR001660	SM00454
571	631	Homologous_superfamily	Sterile alpha motif/pointed domain superfamily	IPR013761	SSF47769
576	629	Domain	Sterile alpha motif domain	IPR001660	PF07647
578	632	Domain	Sterile alpha motif domain	IPR001660	PS50105
666	722	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
675	710	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000043
GO:0015031	protein transport	Biological Process	IEA	GO_REF:0000043
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:18077552
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030163	protein catabolic process	Biological Process	IMP	PMID:18077552
GO:0045806	negative regulation of endocytosis	Biological Process	IMP	PMID:15256501
GO:0046755	viral budding	Biological Process	IMP	PMID:15256501
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:15256501
GO:0070086	ubiquitin-dependent endocytosis	Biological Process	IDA	PMID:15256501
GO:1904417	positive regulation of xenophagy	Biological Process	IMP	PMID:23245322
GO:2000786	positive regulation of autophagosome assembly	Biological Process	IMP	PMID:25484098
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016020	membrane	Cellular Component	IDA	PMID:15256501
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:15256501
GO:0005515	protein binding	Molecular Function	IPI	PMID:15256501
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


P00519	ABL1	Yes	No	No	No	—	No	Cluster-specific

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