KLH24

Details:

UniProt Entry: Q6TFL4
Gene: KLHL24
Class: Other E3 Components
Family: Adaptor
Protein length: 600
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6TFL4
MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEFF DFSSGSSHAE NILQIFNEFR
DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR ESREMLVEIN GILAEAMECF
LQYVYTGKVK ITTENVQYLF ETSSLFQISV LRDACAKFLE EQLDPCNCLG IQRFADTHSL
KTLFTKCKNF ALQTFEDVSQ HEEFLELDKD ELIDYICSDE LVIGKEEMVF EAVMRWVYRA
VDLRRPLLHE LLTHVRLPLL HPNYFVQTVE VDQLIQNSPE CYQLLHEARR YHILGNEMMS
PRTRPRRSTG YSEVIVVVGG CERVGGFNLP YTECYDPVTG EWKSLAKLPE FTKSEYAVCA
LRNDILVSGG RINSRDVWIY NSQLNIWIRV ASLNKGRWRH KMAVLLGKVY VVGGYDGQNR
LSSVECYDSF SNRWTEVAPL KEAVSSPAVT SCVGKLFVIG GGPDDNTCSD KVQSYDPETN
SWLLRAAIPI AKRCITAVSL NNLIYVAGGL TKAIYCYDPV EDYWMHVQNT FSRQENCGMS
VCNGKIYILG GRRENGEATD TILCYDPATS IITGVAAMPR PVSYHGCVTI HRYNEKCFKL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
22	597	Family	BTB-kelch protein	IPR017096	PIRSF037037
40	165	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
46	161	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
48	168	Domain	Kelch-like protein 24, BTB/POZ domain	IPR030596	cd18253
56	162	Domain	BTB/POZ domain	IPR000210	PF00651
66	133	Domain	BTB/POZ domain	IPR000210	PS50097
66	163	Domain	BTB/POZ domain	IPR000210	SM00225
162	239	Domain	Kelch-like protein 24, BACK domain	IPR047071	cd18463
168	270	Domain	BTB/Kelch-associated	IPR011705	SM00875
168	270	Domain	BTB/Kelch-associated	IPR011705	PF07707
300	598	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
313	590	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
314	349	Repeat	Kelch repeat type 1	IPR006652	PF01344
314	363	Repeat	Kelch repeat type 1	IPR006652	SM00612
356	394	Repeat	Kelch repeat type 1	IPR006652	PF01344
364	407	Repeat	Kelch repeat type 1	IPR006652	SM00612
400	440	Repeat	Kelch repeat type 1	IPR006652	PF01344
408	454	Repeat	Kelch repeat type 1	IPR006652	SM00612
446	482	Repeat	Kelch repeat type 1	IPR006652	PF01344
455	502	Repeat	Kelch repeat type 1	IPR006652	SM00612
503	544	Repeat	Kelch repeat type 1	IPR006652	SM00612
536	569	Repeat	Kelch repeat type 1	IPR006652	PF01344
545	592	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IDA	PMID:27798626
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045109	intermediate filament organization	Biological Process	IMP	PMID:27889062
GO:0051865	protein autoubiquitination	Biological Process	IMP	PMID:27798626
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005912	adherens junction	Cellular Component	IEA	GO_REF:0000044
GO:0030057	desmosome	Cellular Component	IEA	GO_REF:0000044
GO:0030424	axon	Cellular Component	IEA	GO_REF:0000044
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0043204	perikaryon	Cellular Component	IEA	GO_REF:0000044
GO:0070161	anchoring junction	Cellular Component	IEA	GO_REF:0000043
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:27798626
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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