KLH17

Details:

UniProt Entry: Q6TDP4
Gene: KLHL17
Class: Other E3 Components
Family: Adaptor
Protein length: 642
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6TDP4
MQPRSERPAG RTQSPEHGSP GPGPEAPPPP PPQPPAPEAE RTRPRQARPA APMEGAVQLL
SREGHSVAHN SKRHYHDAFV AMSRMRQRGL LCDIVLHVAA KEIRAHKVVL ASCSPYFHAM
FTNEMSESRQ THVTLHDIDP QALDQLVQFA YTAEIVVGEG NVQTLLPAAS LLQLNGVRDA
CCKFLLSQLD PSNCLGIRGF ADAHSCSDLL KAAHRYVLQH FVDVAKTEEF MLLPLKQVLE
LVSSDSLNVP SEEEVYRAVL SWVKHDVDAR RQHVPRLMKC VRLPLLSRDF LLGHVDAESL
VRHHPDCKDL LIEALKFHLL PEQRGVLGTS RTRPRRCEGA GPVLFAVGGG SLFAIHGDCE
AYDTRTDRWH VVASMSTRRA RVGVAAVGNR LYAVGGYDGT SDLATVESYD PVTNTWQPEV
SMGTRRSCLG VAALHGLLYS AGGYDGASCL NSAERYDPLT GTWTSVAAMS TRRRYVRVAT
LDGNLYAVGG YDSSSHLATV EKYEPQVNVW SPVASMLSRR SSAGVAVLEG ALYVAGGNDG
TSCLNSVERY SPKAGAWESV APMNIRRSTH DLVAMDGWLY AVGGNDGSSS LNSIEKYNPR
TNKWVAASCM FTRRSSVGVA VLELLNFPPP SSPTLSVSST SL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
52	627	Family	BTB-kelch protein	IPR017096	PIRSF037037
61	190	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
70	187	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
83	188	Domain	BTB/POZ domain	IPR000210	PF00651
92	189	Domain	BTB/POZ domain	IPR000210	SM00225
92	159	Domain	BTB/POZ domain	IPR000210	PS50097
194	296	Domain	BTB/Kelch-associated	IPR011705	SM00875
194	295	Domain	BTB/Kelch-associated	IPR011705	PF07707
334	495	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
342	376	Repeat	Kelch repeat type 1	IPR006652	PF01344
343	389	Repeat	Kelch repeat type 1	IPR006652	SM00612
353	622	Homologous_superfamily	Galactose oxidase/kelch, beta-propeller	IPR011043	SSF50965
378	422	Repeat	Kelch repeat type 1	IPR006652	PF01344
390	436	Repeat	Kelch repeat type 1	IPR006652	SM00612
425	470	Repeat	Kelch repeat type 1	IPR006652	PF01344
437	483	Repeat	Kelch repeat type 1	IPR006652	SM00612
472	516	Repeat	Kelch repeat type 1	IPR006652	PF01344
484	530	Repeat	Kelch repeat type 1	IPR006652	SM00612
496	626	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
519	564	Repeat	Kelch repeat type 1	IPR006652	PF01344
531	577	Repeat	Kelch repeat type 1	IPR006652	SM00612
566	610	Repeat	Kelch repeat type 1	IPR006652	PF01344
578	624	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030036	actin cytoskeleton organization	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005615	extracellular space	Cellular Component	HDA	PMID:22664934
GO:0014069	postsynaptic density	Cellular Component	IEA	GO_REF:0000044
GO:0015629	actin cytoskeleton	Cellular Component	ISS	GO_REF:0000024
GO:0045202	synapse	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0003779	actin binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0060090	molecular adaptor activity	Molecular Function	ISS	GO_REF:0000024
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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