TRAF7

Details:

UniProt Entry: Q6Q0C0
Gene: TRAF7
Class: RING
Family: RING1
Protein length: 670
Database confidence: 0.875
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q6Q0C0
MSSGKSARYN RFSGGPSNLP TPDVTTGTRM ETTFGPAFSA VTTITKADGT STYKQHCRTP
SSSSTLAYSP RDEEDSMPPI STPRRSDSAI SVRSLHSESS MSLRSTFSLP EEEEEPEPLV
FAEQPSVKLC CQLCCSVFKD PVITTCGHTF CRRCALKSEK CPVDNVKLTV VVNNIAVAEQ
IGELFIHCRH GCRVAGSGKP PIFEVDPRGC PFTIKLSARK DHEGSCDYRP VRCPNNPSCP
PLLRMNLEAH LKECEHIKCP HSKYGCTFIG NQDTYETHLE TCRFEGLKEF LQQTDDRFHE
MHVALAQKDQ EIAFLRSMLG KLSEKIDQLE KSLELKFDVL DENQSKLSED LMEFRRDASM
LNDELSHINA RLNMGILGSY DPQQIFKCKG TFVGHQGPVW CLCVYSMGDL LFSGSSDKTI
KVWDTCTTYK CQKTLEGHDG IVLALCIQGC KLYSGSADCT IIVWDIQNLQ KVNTIRAHDN
PVCTLVSSHN VLFSGSLKAI KVWDIVGTEL KLKKELTGLN HWVRALVAAQ SYLYSGSYQT
IKIWDIRTLD CIHVLQTSGG SVYSIAVTNH HIVCGTYENL IHVWDIESKE QVRTLTGHVG
TVYALAVIST PDQTKVFSAS YDRSLRVWSM DNMICTQTLL RHQGSVTALA VSRGRLFSGA
VDSTVKVWTC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
106	200	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
131	164	Domain	Zinc finger, RING-type	IPR001841	SM00184
131	165	Domain	Zinc finger, RING-type	IPR001841	PS50089
131	155	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
146	155	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
204	257	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
222	292	Domain	Zinc finger, TRAF-type	IPR001293	PS50145
378	502	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
385	424	Repeat	WD40 repeat	IPR001680	SM00320
387	424	Repeat	WD40 repeat	IPR001680	PF00400
387	669	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
392	424	Repeat	WD40 repeat	IPR001680	PS50082
411	425	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
428	465	Repeat	WD40 repeat	IPR001680	SM00320
430	465	Repeat	WD40 repeat	IPR001680	PF00400
435	474	Repeat	WD40 repeat	IPR001680	PS50082
452	466	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
452	466	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
468	504	Repeat	WD40 repeat	IPR001680	SM00320
503	670	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
509	545	Repeat	WD40 repeat	IPR001680	SM00320
548	585	Repeat	WD40 repeat	IPR001680	SM00320
555	594	Repeat	WD40 repeat	IPR001680	PS50082
588	629	Repeat	WD40 repeat	IPR001680	SM00320
590	629	Repeat	WD40 repeat	IPR001680	PF00400
595	638	Repeat	WD40 repeat	IPR001680	PS50082
632	669	Repeat	WD40 repeat	IPR001680	SM00320
635	668	Repeat	WD40 repeat	IPR001680	PF00400
639	670	Repeat	WD40 repeat	IPR001680	PS50082
656	670	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0051247	positive regulation of protein metabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:1406630
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:1493333
GO:0043410	positive regulation of MAPK cascade	Biological Process	IDA	PMID:15001576
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	Biological Process	TAS	PMID:27777308
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035519	protein K29-linked ubiquitination	Biological Process	IDA	PMID:21518757
GO:0043525	positive regulation of neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0070372	regulation of ERK1 and ERK2 cascade	Biological Process	IBA	GO_REF:0000033
GO:2001235	positive regulation of apoptotic signaling pathway	Biological Process	IMP	PMID:15001576
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IDA	GO_REF:0000052
GO:0000151	ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:14743216
GO:0005515	protein binding	Molecular Function	IPI	PMID:14743216
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


O43474	KLF4	Yes	No	No	No	—	No	E3-specific
Q6Q0C0	TRAF7	Yes	No	No	No	14743216	EBI-353548	E3-specific

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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
O43474	KLF4	Yes	No	No	No	—	No	E3-specific
Q6Q0C0	TRAF7	Yes	No	No	No	14743216	EBI-353548	E3-specific