SPSB3

Details:

UniProt Entry: Q6PJ21
Gene: SPSB3
Class: Other E3 Components
Family: Receptor
Protein length: 355
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6PJ21
MARRPRNSRA WHFVLSAARR DADARAVALA GSTNWGYDSD GQHSDSDSDP EYSTLPPSIP
SAVPVTGESF CDCAGQSEAS FCSSLHSAHR GRDCRCGEED EYFDWVWDDL NKSSATLLSC
DNRKVSFHME YSCGTAAIRG TKELGEGQHF WEIKMTSPVY GTDMMVGIGT SDVDLDKYRH
TFCSLLGRDE DSWGLSYTGL LHHKGDKTSF SSRFGQGSII GVHLDTWHGT LTFFKNRKCI
GVAATKLQNK RFYPMVCSTA ARSSMKVTRS CASATSLQYL CCHRLRQLRP DSGDTLEGLP
LPPGLKQVLH NKLGWVLSMS CSRRKAPVSD PQAATSAHPS SREPRPCQRK RCRRT

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
85	274	Domain	B30.2/SPRY domain	IPR001870	PS50188
93	286	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
104	286	Domain	SPRY domain-containing SOCS box protein 3, SPRY domain	IPR035754	cd12876
109	270	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
146	274	Domain	SPRY domain	IPR003877	SM00449
149	261	Domain	SPRY domain	IPR003877	PF00622
272	309	Domain	SOCS box domain	IPR001496	PS50225
274	312	Domain	SOCS box domain	IPR001496	SM00969

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001837	epithelial to mesenchymal transition	Biological Process	IDA	PMID:16096638
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:34518685
GO:0140896	cGAS/STING signaling pathway	Biological Process	IDA	PMID:30842659
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0010719	negative regulation of epithelial to mesenchymal transition	Biological Process	IDA	PMID:29059170
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0070936	protein K48-linked ubiquitination	Biological Process	IDA	PMID:38418882
GO:0160049	negative regulation of cGAS/STING signaling pathway	Biological Process	IDA	PMID:38418882
GO:0005634	nucleus	Cellular Component	IDA	PMID:38418882
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952039
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IDA	PMID:29059170
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IEA	GO_REF:0000117

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