FBX38

Details:

UniProt Entry: Q6PIJ6
Gene: FBXO38
Class: Other E3 Components
Family: Receptor
Protein length: 1188
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6PIJ6
MGPRKKSVKT CIMNNEIPEE MTADETKDYM NQLSHEVLCH IFRYLPLQDI MCMECLSRKL
KEAVTLYLRV VRVVDLCAGR WWEYMPSGFT DASFLTLLKK MPDVEQLYGL HPRYLERRRV
RGHEAFSIPG VLEALQACPN LVGVETSHLE LVESIWTYMP HVHILGKFRN RNGAFPIPPE
NKLKIPIGAK IQTLHLVGVN VPEIPCIPML RHLYMKWVRL TKPQPFKDFL CISLRTFVMR
NCAGPTNSLK YVPLVTGLAS ARNLEHLEMV RVPFLGGLIQ HVVEDSWRSG GFRNLHTIVL
GACKNALEVD LGYLIITAAR RLHEVRIQPS LTKDGVFSAL KMAELEFPQF ETLHLGYVDE
FLLQSRMANA DLVKYGLADV VENPGIITDI GMKAVNEVFS CIKYLAIYNC PHLHNPYNWI
SDHSRWTRLV DINLVRCHAL KLDSFGQFIE LLPSLEFISL DQMFREPPKG CARVGLSAGT
GIGVSSALVS NQNSNNDDNN AQNNNANIHD NNHHHPDDSD EENDFRQDLQ PGEQQFAADA
LNEMEDIVQE DGEVVAESGN NTPAHSQAII PVDVDEEQAG PSGLQRVVKP TSITVHDSES
DDEEDSLELQ EVWIPKNGTR RYSEREEKTG ESVQSRELSV SGKGKTPLRK RYNSHQMGQS
KQFPLEESSC EKGCQVTSEQ IKADMKAARD IPEKKKNKDV YPSCSSTTAS TVGNSSSHNT
ASQSPDFVRT VNSGGSSEPS PTEVDVSRQC ACSPGGSEDS EAMEEGDAES SVCPRCCCHR
PQESQRRTSR CSDEERPSTS RACVVNGPDG TRSAFSFRTL PQGGSSGPAH DERTNGSGSG
ATGEDRRGSS QPESCDVQSN EDYPRRPLTR ARSRLSHVLL VSESEVAKTK PRHAMKRKRT
ADKSTSTSDP VIEDDHVQVL VLKSKNLVGV TMTNCGITDL VLKDCPKMMF IHATRCRVLK
HLKVENAPIV NRFDYAQCKK LNMDQVLDQI LRMPPERNRI IYLRPMQQVD TLTLEQKLFS
GPYPYHICII HEFSNPPNVR NKVRIRSWMD TIANINQELI KYEFFPEATR SEEDLKKYPK
YPWGREIYTL EGVVDGAPYS MISDFPWLRS LRAAEPNSFA RYDFEDDEES TIYAPRRKGQ
LSADICMETI GEEISEMRQM KKGVFQRVVA IFIHYCDVNG EPVEDDYI

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	1188	Family	F-box only protein 38	IPR042354	PTHR14753
27	103	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
32	64	Domain	F-box domain	IPR001810	PF00646
114	488	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0002841	negative regulation of T cell mediated immune response to tumor cell	Biological Process	IDA	PMID:37208329
GO:0010976	positive regulation of neuron projection development	Biological Process	IDA	PMID:24207122
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:37534934
GO:0050868	negative regulation of T cell activation	Biological Process	IDA	PMID:38377992
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000043
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	Biological Process	IDA	PMID:30487606
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0050870	positive regulation of T cell activation	Biological Process	IDA	PMID:30487606
GO:0070936	protein K48-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	TAS	PMID:30487606
GO:0005515	protein binding	Molecular Function	IPI	PMID:30487606
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:30487606

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