KLH35

Details:

UniProt Entry: Q6PF15
Gene: KLHL35
Class: Other E3 Components
Family: Adaptor
Protein length: 583
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6PF15
MRQGHAPEES EPGCEAPCAG PCHAQRVLQA LNAYRRSGTL TDVVLRAGGR DFPCHRAALS
AGSAYFRSLF AAGRPERGPA VVPVVPVAPE APGTSPAGAA AALAVVLDYV YGAGVRLRAE
DEAAAVLALA ERLGVAGLRE ACVRFLEGRL RAANSLALRR VAAAFSLAPL AERCGRVLRQ
AFAEVARHAD FLELAPDEVV ALLADPALGV AREEAVFEAA MRWVRHDAPA RRGQLRRLLE
HVRLPLLAPA YFLEKVEADE LLQACGECRP LLLEARACFI LGREAGALRT RPRRFMDLAE
VIVVIGGCDR KGLLKLPFAD AYHPESQRWT PLPSLPGYTR SEFAACALRN DVYVSGGHIN
SHDVWMFSSH LHTWIKVASL HKGRWRHKMA VVQGQLFAVG GFDGLRRLHS VERYDPFSNT
WAAAAPLPEA VSSAAVASCA GKLFVIGGAR QGGVNTDKVQ CFDPKEDRWS LRSPAPFSQR
CLEAVSLEDT IYVMGGLMSK IFTYDPGTDV WGEAAVLPSP VESCGVTVCD GKVHILGGRD
DRGESTDKVF TFDPSSGQVE VQPSLQRCTS SHGCVTIIQS LGR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	581	Family	BTB-kelch protein	IPR017096	PIRSF037037
18	151	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
21	147	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
31	148	Domain	BTB/POZ domain	IPR000210	PF00651
41	119	Domain	BTB/POZ domain	IPR000210	PS50097
41	150	Domain	BTB/POZ domain	IPR000210	SM00225
155	257	Domain	BTB/Kelch-associated	IPR011705	SM00875
156	256	Domain	BTB/Kelch-associated	IPR011705	PF07707
287	581	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
300	577	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
301	350	Repeat	Kelch repeat type 1	IPR006652	SM00612
340	380	Repeat	Kelch repeat type 1	IPR006652	PF01344
351	394	Repeat	Kelch repeat type 1	IPR006652	SM00612
387	428	Repeat	Kelch repeat type 1	IPR006652	PF01344
395	441	Repeat	Kelch repeat type 1	IPR006652	SM00612
432	471	Repeat	Kelch repeat type 1	IPR006652	PF01344
442	489	Repeat	Kelch repeat type 1	IPR006652	SM00612
490	531	Repeat	Kelch repeat type 1	IPR006652	SM00612
524	565	Repeat	Kelch repeat type 1	IPR006652	PF01344
532	579	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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