FXL19

Details:

UniProt Entry: Q6PCT2
Gene: FBXL19
Class: RING
Family: RING7
Protein length: 694
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link
PDB Structures: 6asb

Protein Sequence ▾

>Q6PCT2
MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK
KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEEEKFGLS LMECTICNEI
VHPGCLKMGK AEGVINAEIP NCWECPRCTQ EGRTSKDSGE GPGRRRADNG EEGASLGSGW
KLTEEPPLPP PPPRRKGPLP AGPPPEDVPG PPKRKEREAG NEPPTPRKKV KGGRERHLKK
VGGDACLLRG SDPGGPGLLP PRVLNPSQAF SSCHPGLPPE NWEKPKPPLA SAEGPAVPSP
SPQREKLERF KRMCQLLERV PDTSSSSSDS DSDSDSSGTS LSEDEAPGEA RNGRRPARGS
SGEKENRGGR RAVRPGSGGP LLSWPLGPAP PPRPPQLERH VVRPPPRSPE PDTLPLAAGS
DHPLPRAAWL RVFQHLGPRE LCICMRVCRT WSRWCYDKRL WPRMDLSRRK SLTPPMLSGV
VRRQPRALDL SWTGVSKKQL MWLLNRLQGL QELVLSGCSW LSVSALGSAP LPALRLLDLR
WIEDVKDSQL RELLLPPPDT KPGQTESRGR LQGVAELRLA GLELTDASLR LLLRHAPQLS
ALDLSHCAHV GDPSVHLLTA PTSPLRETLV HLNLAGCHRL TDHCLPLFRR CPRLRRLDLR
SCRQLSPEAC ARLAAAGPPG PFRCPEEKLL LKDS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
32	78	Domain	Zinc finger, CXXC-type	IPR002857	PS51058
33	77	Domain	Zinc finger, CXXC-type	IPR002857	PF02008
73	149	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
81	152	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
82	149	Domain	Zinc finger, PHD-finger	IPR019787	PF16866
85	151	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
87	149	Domain	Zinc finger, PHD-type	IPR001965	SM00249
88	148	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
420	678	Homologous_superfamily	Leucine-rich repeat domain superfamily	IPR032675	G3DSA:3.80.10.10
424	464	Domain	F-box domain	IPR001810	SM00256
424	462	Domain	F-box domain	IPR001810	PF00646
596	621	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367
651	676	Repeat	Leucine-rich repeat, cysteine-containing subtype	IPR006553	SM00367

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0016477	cell migration	Biological Process	IDA	PMID:23512198
GO:0006338	chromatin remodeling	Biological Process	IBA	GO_REF:0000033
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IC	PMID:22660580
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IDA	PMID:22660580
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0045322	unmethylated CpG binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003712	transcription coregulator activity	Molecular Function	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:22660580
GO:0032452	histone demethylase activity	Molecular Function	IBA	GO_REF:0000033
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:22660580

Enzyme–Substrate Interactions ▾


P43699	NKX21	Yes	No	No	No	—	No	E3-specific
Q01638	ILRL1	Yes	Yes	No	No	—	No	E3-specific
P60953	CDC42	Yes	No	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P43699	NKX21	Yes	No	No	No	—	No	E3-specific
Q01638	ILRL1	Yes	Yes	No	No	—	No	E3-specific
P60953	CDC42	Yes	No	No	No	—	No	E3-specific