RFWD3

Details:

UniProt Entry: Q6PCD5
Gene: RFWD3
Class: RING
Family: RING9
Protein length: 774
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 6cvz

Protein Sequence ▾

>Q6PCD5
MAHEAMEYDV QVQLNHAEQQ PAPAGMASSQ GGPALLQPVP ADVVSSQGVP SILQPAPAEV
ISSQATPPLL QPAPQLSVDL TEVEVLGEDT VENINPRTSE QHRQGSDGNH TIPASSLHSM
TNFISGLQRL HGMLEFLRPS SSNHSVGPMR TRRRVSASRR ARAGGSQRTD SARLRAPLDA
YFQVSRTQPD LPATTYDSET RNPVSEELQV SSSSDSDSDS SAEYGGVVDQ AEESGAVILE
EQLAGVSAEQ EVTCIDGGKT LPKQPSPQKS EPLLPSASMD EEEGDTCTIC LEQWTNAGDH
RLSALRCGHL FGYRCISTWL KGQVRKCPQC NKKARHSDIV VLYARTLRAL DTSEQERMKS
SLLKEQMLRK QAELESAQCR LQLQVLTDKC TRLQRRVQDL QKLTSHQSQN LQQPRGSQAW
VLSCSPSSQG QHKHKYHFQK TFTVSQAGNC RIMAYCDALS CLVISQPSPQ ASFLPGFGVK
MLSTANMKSS QYIPMHGKQI RGLAFSSYLR GLLLSASLDN TIKLTSLETN TVVQTYNAGR
PVWSCCWCLD EANYIYAGLA NGSILVYDVR NTSSHVQELV AQKARCPLVS LSYMPRAASA
AFPYGGVLAG TLEDASFWEQ KMDFSHWPHV LPLEPGGCID FQTENSSRHC LVTYRPDKNH
TTIRSVLMEM SYRLDDTGNP ICSCQPVHTF FGGPTCKLLT KNAIFQSPEN DGNILVCTGD
EAANSALLWD AASGSLLQDL QTDQPVLDIC PFEVNRNSYL ATLTEKMVHI YKWE

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
172	773	Family	E3 ubiquitin-protein ligase RFWD3	IPR037381	PTHR16047
273	366	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
285	331	Domain	Zinc finger, RING-type	IPR001841	PF13639
287	330	Domain	Zinc finger, RING-type	IPR001841	SM00184
287	331	Domain	Zinc finger, RING-type	IPR001841	PS50089
396	774	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
478	752	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
486	526	Repeat	WD40 repeat	IPR001680	SM00320
529	568	Repeat	WD40 repeat	IPR001680	SM00320
733	772	Repeat	WD40 repeat	IPR001680	SM00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000724	double-strand break repair via homologous recombination	Biological Process	IDA	PMID:26474068
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0010212	response to ionizing radiation	Biological Process	IDA	PMID:20173098
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0031297	replication fork processing	Biological Process	IBA	GO_REF:0000033
GO:0031571	mitotic G1 DNA damage checkpoint signaling	Biological Process	IMP	PMID:20173098
GO:0036297	interstrand cross-link repair	Biological Process	IEA	GO_REF:0000002
GO:2000001	regulation of DNA damage checkpoint	Biological Process	IMP	PMID:21504906
GO:0035861	site of double-strand break	Cellular Component	IDA	PMID:21504906
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0090734	site of DNA damage	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0016605	PML body	Cellular Component	IEA	GO_REF:0000044
GO:0002039	p53 binding	Molecular Function	IPI	PMID:20173098
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0097371	MDM2/MDM4 family protein binding	Molecular Function	IPI	PMID:20173098

Enzyme–Substrate Interactions ▾


Q06609	RAD51	Yes	No	No	No	—	No	E3-specific

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