TRI40

Details:

UniProt Entry: Q6P9F5
Gene: TRIM40
Class: RING
Family: RING5
Protein length: 258
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q6P9F5
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV FCCPLCRKPC
SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM SHHELTIENA LSHYKERLNR
RSRKLRKDIA ELQRLKAQQE KKLQALQFQV DHGNHRLEAG PESQHQTREQ LGALPQQWLG
QLEHMPAEAA RILDISRAVT QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY
PQLEKGVSEL LLQPPQKL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	61	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
14	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
14	54	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
14	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
29	38	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
66	107	Domain	B-box-type zinc finger	IPR000315	PS50119

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0030308	negative regulation of cell growth	Biological Process	IEA	GO_REF:0000107
GO:0032088	negative regulation of NF-kappaB transcription factor activity	Biological Process	IDA	PMID:21474709
GO:0042177	negative regulation of protein catabolic process	Biological Process	IDA	PMID:21474709
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0045116	protein neddylation	Biological Process	IDA	PMID:21474709
GO:1900181	negative regulation of protein localization to nucleus	Biological Process	IDA	PMID:21474709
GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	Biological Process	NAS	PMID:21474709
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008385	IkappaB kinase complex	Cellular Component	IDA	PMID:21474709
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:21474709
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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