FXL22

Details:

UniProt Entry: Q6P050
Gene: FBXL22
Class: Other E3 Components
Family: Receptor
Protein length: 247
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6P050
MWPLLTMHIT QLNRECLLHL FSFLDKDSRK SLARTCSQLH DVFEDPALWS LLHFRSLTEL
QKDNFLLGPA LRSLSICWHS SRVQVCSIED WLKSAFQRSI CSRHESLVND FLLRVCDRLS
AVRSPRRREA PAPSSGTPIA VGPKSPRWGG PDHSEFADLR SGVTGARAAA RRGLGSLRAE
RPSETPPAPG VSWGPPPPGA PVVISVKQEE GKQGRTGRRS HRAAPPCGFA RTRVCPPTFP
GADAFPQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	60	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
15	54	Domain	F-box domain	IPR001810	PF12937

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:22972877
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0030018	Z disc	Cellular Component	IEA	GO_REF:0000120
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0005515	protein binding	Molecular Function	IPI	PMID:22972877
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IDA	PMID:22972877

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.