KLH10

Details:

UniProt Entry: Q6JEL2
Gene: KLHL10
Class: Other E3 Components
Family: Adaptor
Protein length: 608
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q6JEL2
MEMESAAAST RFHQPHMERK MSAMACEIFN ELRLEGKLCD VVIKVNGFEF SAHKNILCSC
SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN
IMGIVRGCCE FLKSELCLDN CIGICKFTDY YYCPELRQKA YMFILHNFEE MVKVSAEFLE
LSVTELKDII EKDELNVKQE DAVFEAILKW ISHDPQNRKQ HISILLPKVR LALMHAEYFM
NNVKMNDYVK DSEECKPVII NALKAMYDLN MNGPSNSDFT NPLTRPRLPY AILFAIGGWS
GGSPTNAIEA YDARADRWVN VTCEEESPRA YHGAAYLKGY VYIIGGFDSV DYFNSVKRFD
PVKKTWHQVA PMHSRRCYVS VTVLGNFIYA MGGFDGYVRL NTAERYEPET NQWTLIAPMH
EQRSDASATT LYGKVYICGG FNGNECLFTA EVYNTESNQW TVIAPMRSRR SGIGVIAYGE
HVYAVGGFDG ANRLRSAEAY SPVANTWRTI PTMFNPRSNF GIEVVDDLLF VVGGFNGFTT
TFNVECYDEK TDEWYDAHDM SIYRSALSCC VVPGLANVEE YAARRDNFPG LALRDEVKYS
ASTSTLPV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	579	Family	BTB-kelch protein	IPR017096	PIRSF037037
19	139	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
22	141	Domain	Kelch-like protein 10, BTB/POZ domain	IPR030608	cd18240
25	134	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
29	134	Domain	BTB/POZ domain	IPR000210	PF00651
39	136	Domain	BTB/POZ domain	IPR000210	SM00225
39	106	Domain	BTB/POZ domain	IPR000210	PS50097
141	244	Domain	BTB/Kelch-associated	IPR011705	SM00875
141	243	Domain	BTB/Kelch-associated	IPR011705	PF07707
285	577	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
292	339	Repeat	Kelch repeat type 1	IPR006652	SM00612
293	572	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
293	321	Repeat	Kelch repeat type 1	IPR006652	PF01344
328	372	Repeat	Kelch repeat type 1	IPR006652	PF01344
340	386	Repeat	Kelch repeat type 1	IPR006652	SM00612
375	419	Repeat	Kelch repeat type 1	IPR006652	PF01344
387	433	Repeat	Kelch repeat type 1	IPR006652	SM00612
423	467	Repeat	Kelch repeat type 1	IPR006652	PF01344
434	480	Repeat	Kelch repeat type 1	IPR006652	SM00612
469	513	Repeat	Kelch repeat type 1	IPR006652	PF01344
481	527	Repeat	Kelch repeat type 1	IPR006652	SM00612
516	560	Repeat	Kelch repeat type 1	IPR006652	PF01344
528	574	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000902	cell morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0007286	spermatid development	Biological Process	IEA	GO_REF:0000107
GO:0008584	male gonad development	Biological Process	IEA	GO_REF:0000107
GO:0009566	fertilization	Biological Process	IEA	GO_REF:0000107
GO:0048808	male genitalia morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0048873	homeostasis of number of cells within a tissue	Biological Process	IEA	GO_REF:0000107
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000043
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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