JADE1

Details:

UniProt Entry: Q6IE81
Gene: JADE1
Class: RING
Family: RING7
Protein length: 842
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q6IE81
MKRGRLPSSS EDSDDNGSLS TTWSQNSRSQ HRRSSCSRHE DRKPSEVFRT DLITAMKLHD
SYQLNPDEYY VLADPWRQEW EKGVQVPVSP GTIPQPVARV VSEEKSLMFI RPKKYIVSSG
SEPPELGYVD IRTLADSVCR YDLNDMDAAW LELTNEEFKE MGMPELDEYT MERVLEEFEQ
RCYDNMNHAI ETEEGLGIEY DEDVVCDVCQ SPDGEDGNEM VFCDKCNICV HQACYGILKV
PEGSWLCRTC ALGVQPKCLL CPKKGGAMKP TRSGTKWVHV SCALWIPEVS IGSPEKMEPI
TKVSHIPSSR WALVCSLCNE KFGASIQCSV KNCRTAFHVT CAFDRGLEMK TILAENDEVK
FKSYCPKHSS HRKPEESLGK GAAQENGAPE CSPRNPLEPF ASLEQNREEA HRVSVRKQKL
QQLEDEFYTF VNLLDVARAL RLPEEVVDFL YQYWKLKRKV NFNKPLITPK KDEEDNLAKR
EQDVLFRRLQ LFTHLRQDLE RVRNLTYMVT RREKIKRSVC KVQEQIFNLY TKLLEQERVS
GVPSSCSSSS LENMLLFNSP SVGPDAPKIE DLKWHSAFFR KQMGTSLVHS LKKPHKRDPL
QNSPGSEGKT LLKQPDLCGR REGMVVPESF LGLEKTFAEA RLISAQQKNG VVMPDHGKRR
DNRFHCDLIK GDLKDKSFKQ SHKPLRSTDV SQRHLDNTRA ATSPGVGQSA PGTRKEIVPK
CNGSLIKVNY NQTAVKVPTT PASPVKNWGG FRIPKKGERQ QQGEAHDGAC HQHSDYPYLG
LGRVPAKERA KSKLKSDNEN DGYVPDVEMS DSESEASEKK CIHTSSTISR RTDIIRRSIL
AS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
26	180	Domain	Enhancer of polycomb-like, N-terminal	IPR019542	PF10513
193	253	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
195	265	Homologous_superfamily	Zinc finger, FYVE/PHD-type	IPR011011	SSF57903
203	253	Domain	Zinc finger, PHD-finger	IPR019787	PS50016
205	250	Domain	Jade-1, PHD finger	IPR039546	cd15679
205	251	Domain	Zinc finger, PHD-type	IPR001965	SM00249
206	250	Conserved_site	Zinc finger, PHD-type, conserved site	IPR019786	PS01359
254	371	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
255	369	Domain	Extended PHD (ePHD) domain	IPR034732	PS51805
314	369	Domain	Zinc finger, PHD-type	IPR001965	SM00249

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Biological Process	IDA	PMID:23001567
GO:0001558	regulation of cell growth	Biological Process	IDA	PMID:22144582
GO:0006275	regulation of DNA replication	Biological Process	IEA	GO_REF:0000117
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0006355	regulation of DNA-templated transcription	Biological Process	IDA	PMID:22144582
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000043
GO:0030308	negative regulation of cell growth	Biological Process	NAS	PMID:12169691
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IEA	GO_REF:0000108
GO:0051726	regulation of cell cycle	Biological Process	IEA	GO_REF:0000117
GO:0090090	negative regulation of canonical Wnt signaling pathway	Biological Process	IDA	PMID:22654112
GO:2000278	regulation of DNA biosynthetic process	Biological Process	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005694	chromosome	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0005886	plasma membrane	Cellular Component	IDA	PMID:23001567
GO:0016607	nuclear speck	Cellular Component	IDA	PMID:12169691
GO:0036064	ciliary basal body	Cellular Component	IDA	PMID:22654112
GO:0042995	cell projection	Cellular Component	IEA	GO_REF:0000043
GO:0000123	histone acetyltransferase complex	Cellular Component	IBA	GO_REF:0000033
GO:0046972	histone H4K16 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0036408	histone H3K14 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043995	histone H4K5 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043996	histone H4K8 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0043997	histone H4K12 acetyltransferase activity	Molecular Function	IDA	PMID:16387653
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:23001567
GO:0005515	protein binding	Molecular Function	IPI	PMID:12169691
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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