OTU7B

Details:

UniProt Entry: Q6GQQ9
Gene: OTUD7B
Class: RING
Family: RING7
Protein length: 843
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 5lru, 5lrv, 5lrw

Protein Sequence ▾

>Q6GQQ9
MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVNAALSD FEQLRQVHAG NLPPSFSEGS
GGSRTPEKGF SDREPTRPPR PILQRQDDIV QEKRLSRGIS HASSSIVSLA RSHVSSNGGG
GGSNEHPLEM PICAFQLPDL TVYNEDFRSF IERDLIEQSM LVALEQAGRL NWWVSVDPTS
QRLLPLATTG DGNCLLHAAS LGMWGFHDRD LMLRKALYAL MEKGVEKEAL KRRWRWQQTQ
QNKESGLVYT EDEWQKEWNE LIKLASSEPR MHLGTNGANC GGVESSEEPV YESLEEFHVF
VLAHVLRRPI VVVADTMLRD SGGEAFAPIP FGGIYLPLEV PASQCHRSPL VLAYDQAHFS
ALVSMEQKEN TKEQAVIPLT DSEYKLLPLH FAVDPGKGWE WGKDDSDNVR LASVILSLEV
KLHLLHSYMN VKWIPLSSDA QAPLAQPESP TASAGDEPRS TPESGDSDKE SVGSSSTSNE
GGRRKEKSKR DREKDKKRAD SVANKLGSFG KTLGSKLKKN MGGLMHSKGS KPGGVGTGLG
GSSGTETLEK KKKNSLKSWK GGKEEAAGDG PVSEKPPAES VGNGGSKYSQ EVMQSLSILR
TAMQGEGKFI FVGTLKMGHR HQYQEEMIQR YLSDAEERFL AEQKQKEAER KIMNGGIGGG
PPPAKKPEPD AREEQPTGPP AESRAMAFST GYPGDFTIPR PSGGGVHCQE PRRQLAGGPC
VGGLPPYATF PRQCPPGRPY PHQDSIPSLE PGSHSKDGLH RGALLPPPYR VADSYSNGYR
EPPEPDGWAG GLRGLPPTQT KCKQPNCSFY GHPETNNFCS CCYREELRRR EREPDGELLV
HRF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
183	365	Domain	OTU domain	IPR003323	PS50802
189	359	Domain	OTU domain	IPR003323	PF02338
796	831	Domain	Zinc finger, A20-type	IPR002653	PS51036
799	824	Domain	Zinc finger, A20-type	IPR002653	SM00259
801	824	Domain	Zinc finger, A20-type	IPR002653	PF01754

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006508	proteolysis	Biological Process	IEA	GO_REF:0000043
GO:0035871	protein K11-linked deubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0032717	negative regulation of interleukin-8 production	Biological Process	IDA	PMID:21097510
GO:0001701	in utero embryonic development	Biological Process	IEA	GO_REF:0000107
GO:0016579	protein deubiquitination	Biological Process	IEA	GO_REF:0000107
GO:0038202	TORC1 signaling	Biological Process	IDA	PMID:26678875
GO:0038203	TORC2 signaling	Biological Process	IDA	PMID:35926713
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000120
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000043
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0002385	mucosal immune response	Biological Process	ISS	GO_REF:0000024
GO:0043124	negative regulation of canonical NF-kappaB signal transduction	Biological Process	IBA	GO_REF:0000033
GO:0070536	protein K63-linked deubiquitination	Biological Process	IDA	PMID:20622874
GO:0071108	protein K48-linked deubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:1900181	negative regulation of protein localization to nucleus	Biological Process	IDA	PMID:21097510
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:28489822
GO:1904515	positive regulation of TORC2 signaling	Biological Process	IDA	PMID:28489822
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-5690870
GO:0004843	cysteine-type deubiquitinase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008233	peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008234	cysteine-type peptidase activity	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016787	hydrolase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:11463333
GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	Molecular Function	IBA	GO_REF:0000033
GO:1990380	K48-linked deubiquitinase activity	Molecular Function	IDA	PMID:21097510

Enzyme–Substrate Interactions ▾

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