PLAG1

Details:

UniProt Entry: Q6DJT9
Gene: PLAG1
Class: RING
Family: RING6
Protein length: 500
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q6DJT9
MATVIPGDLS EVRDTQKVPS GKRKRGETKP RKNFPCQLCD KAFNSVEKLK VHSYSHTGER
PYKCIQQDCT KAFVSKYKLQ RHMATHSPEK THKCNYCEKM FHRKDHLKNH LHTHDPNKET
FKCEECGKNY NTKLGFKRHL ALHAATSGDL TCKVCLQTFE STGVLLEHLK SHAGKSSGGV
KEKKHQCEHC DRRFYTRKDV RRHMVVHTGR KDFLCQYCAQ RFGRKDHLTR HMKKSHNQEL
LKVKTEPVDF LDPFTCNVSV PIKDELLPVM SLPSSELLSK PFTNTLQLNL YNTPFQSMQS
SGSAHQMITT LPLGMTCPID MDTVHPSHHL SFKYPFSSTS YAISIPEKEQ PLKGEIESYL
MELQGGVPSS SQDSQASSSS KLGLDPQIGS LDDGAGDLSL SKSSISISDP LNTPALDFSQ
LFNFIPLNGP PYNPLSVGSL GMSYSQEEAH SSVSQLPPQT QDLQDPANTI GLGSLHSLSA
AFTSSLSTST TLPRFHQAFQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
34	56	Domain	Zinc finger C2H2-type	IPR013087	SM00355
34	61	Domain	Zinc finger C2H2-type	IPR013087	PS50157
36	56	Domain	Zinc finger C2H2-type	IPR013087	PS00028
42	101	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
62	91	Domain	Zinc finger C2H2-type	IPR013087	PS50157
62	86	Domain	Zinc finger C2H2-type	IPR013087	SM00355
63	86	Domain	Zinc finger C2H2-type	IPR013087	PF00096
64	86	Domain	Zinc finger C2H2-type	IPR013087	PS00028
87	132	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
92	119	Domain	Zinc finger C2H2-type	IPR013087	PS50157
92	114	Domain	Zinc finger C2H2-type	IPR013087	SM00355
94	114	Domain	Zinc finger C2H2-type	IPR013087	PS00028
120	172	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
121	143	Domain	Zinc finger C2H2-type	IPR013087	PF00096
121	143	Domain	Zinc finger C2H2-type	IPR013087	SM00355
121	148	Domain	Zinc finger C2H2-type	IPR013087	PS50157
123	143	Domain	Zinc finger C2H2-type	IPR013087	PS00028
150	172	Domain	Zinc finger C2H2-type	IPR013087	SM00355
150	177	Domain	Zinc finger C2H2-type	IPR013087	PS50157
152	172	Domain	Zinc finger C2H2-type	IPR013087	PS00028
183	233	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
185	207	Domain	Zinc finger C2H2-type	IPR013087	SM00355
185	212	Domain	Zinc finger C2H2-type	IPR013087	PS50157
187	207	Domain	Zinc finger C2H2-type	IPR013087	PS00028
213	236	Domain	Zinc finger C2H2-type	IPR013087	SM00355
213	241	Domain	Zinc finger C2H2-type	IPR013087	PS50157
214	236	Domain	Zinc finger C2H2-type	IPR013087	PF00096
215	236	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0022612	gland morphogenesis	Biological Process	IEA	GO_REF:0000107
GO:0035264	multicellular organism growth	Biological Process	IEA	GO_REF:0000107
GO:0035265	organ growth	Biological Process	IEA	GO_REF:0000107
GO:0060736	prostate gland growth	Biological Process	IEA	GO_REF:0000107
GO:0006355	regulation of DNA-templated transcription	Biological Process	IBA	GO_REF:0000033
GO:0010628	positive regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010629	negative regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:10646861
GO:0060252	positive regulation of glial cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005813	centrosome	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IEA	GO_REF:0000117
GO:0016607	nuclear speck	Cellular Component	IDA	GO_REF:0000052
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IEA	GO_REF:0000117
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003700	DNA-binding transcription factor activity	Molecular Function	TAS	PMID:9722527
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.