TRI68

Details:

UniProt Entry: Q6AZZ1
Gene: TRIM68
Class: RING
Family: RING5
Protein length: 485
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q6AZZ1
MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC
RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC
SQSPEHEAHS VVPMEDVAWE YKWELHEALE HLKKEQEEAW KLEVGERKRT ATWKIQVETR
KQSIVWEFEK YQRLLEKKQP PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV
LWRMIAELKE RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT
YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS QCISSGRHYW
EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK GNEYRAGTDE YPILSLPVPP
RRVGIFVDYE AHDISFYNVT DCGSHIFTFP RYPFPGRLLP YFSPCYSIGT NNTAPLAICS
LDGED

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	87	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
13	61	Domain	E3 ubiquitin-protein ligase TRIM68, RING finger, HC subclass	IPR042656	cd16610
16	60	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	61	Domain	Zinc finger, RING-type	IPR001841	PS50089
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
93	134	Domain	B-box-type zinc finger	IPR000315	SM00336
93	134	Domain	B-box-type zinc finger	IPR000315	PS50119
96	134	Domain	B-box-type zinc finger	IPR000315	PF00643
285	481	Domain	B30.2/SPRY domain	IPR001870	PS50188
295	480	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
296	484	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
301	318	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
302	354	Domain	SPRY-associated	IPR006574	SM00589
305	352	Domain	SPRY-associated	IPR006574	PF13765
318	335	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
340	364	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
355	482	Domain	SPRY domain	IPR003877	SM00449
357	463	Domain	SPRY domain	IPR003877	PF00622
370	383	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
414	438	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
446	464	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:18451177
GO:0060765	regulation of androgen receptor signaling pathway	Biological Process	IDA	PMID:18451177
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0005794	Golgi apparatus	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:18451177
GO:0005515	protein binding	Molecular Function	IPI	PMID:28514442
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0035035	histone acetyltransferase binding	Molecular Function	IPI	PMID:18451177
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0050681	nuclear androgen receptor binding	Molecular Function	IPI	PMID:18451177
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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