KCD11

Details:

UniProt Entry: Q693B1
Gene: KCTD11
Class: Other E3 Components
Family: Adaptor
Protein length: 232
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q693B1
MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE
ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD
TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW
TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	82	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
15	76	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
22	69	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
88	231	Domain	BTB/POZ domain-containing protein KCTD11/21, C-terminal domain	IPR045763	PF19329

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0034220	monoatomic ion transmembrane transport	Biological Process	IEA	GO_REF:0000043
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0007224	smoothened signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0007405	neuroblast proliferation	Biological Process	IEA	GO_REF:0000107
GO:0014016	neuroblast differentiation	Biological Process	IEA	GO_REF:0000107
GO:0007399	nervous system development	Biological Process	IEA	GO_REF:0000107
GO:0007406	negative regulation of neuroblast proliferation	Biological Process	IEA	GO_REF:0000107
GO:0030182	neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0042127	regulation of cell population proliferation	Biological Process	IEA	GO_REF:0000107
GO:0045666	positive regulation of neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000107
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4635266	ChEMBL	6.3	—	—	CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C

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