RNF43

Details:

UniProt Entry: Q68DV7
Gene: RNF43
Class: RING
Family: RING9
Protein length: 783
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 4kng

Protein Sequence ▾

>Q68DV7
MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK
LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL
SLASKARMAG ERGASAVLFD ITEDRAAAEQ LQQPLGLTWP VVLIWGNDAE KLMEFVYKNQ
KAHVRIELKE PPAWPDYDVW ILMTVVGTIF VIILASVLRI RCRPRHSRPD PLQQRTAWAI
SQLATRRYQA SCRQARGEWP DSGSSCSSAP VCAICLEEFS EGQELRVISC LHEFHRNCVD
PWLHQHRTCP LCMFNITEGD SFSQSLGPSR SYQEPGRRLH LIRQHPGHAH YHLPAAYLLG
PSRSAVARPP RPGPFLPSQE PGMGPRHHRF PRAAHPRAPG EQQRLAGAQH PYAQGWGLSH
LQSTSQHPAA CPVPLRRARP PDSSGSGESY CTERSGYLAD GPASDSSSGP CHGSSSDSVV
NCTDISLQGV HGSSSTFCSS LSSDFDPLVY CSPKGDPQRV DMQPSVTSRP RSLDSVVPTG
ETQVSSHVHY HRHRHHHYKK RFQWHGRKPG PETGVPQSRP PIPRTQPQPE PPSPDQQVTR
SNSAAPSGRL SNPQCPRALP EPAPGPVDAS SICPSTSSLF NLQKSSLSAR HPQRKRRGGP
SEPTPGSRPQ DATVHPACQI FPHYTPSVAY PWSPEAHPLI CGPPGLDKRL LPETPGPCYS
NSQPVWLCLT PRQPLEPHPP GEGPSEWSSD TAEGRPCPYP HCQVLSAQPG SEEELEELCE
QAV

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
85	189	Domain	ZNRF-3, ectodomain	IPR040700	PF18212
239	322	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
270	316	Domain	E3 ubiquitin-protein ligase RNF43, Zinc finger, RING-type	IPR045907	cd16798
271	312	Domain	Zinc finger, RING-type	IPR001841	PF13639
272	312	Domain	Zinc finger, RING-type	IPR001841	PS50089
272	312	Domain	Zinc finger, RING-type	IPR001841	SM00184

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0038018	Wnt receptor catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0030178	negative regulation of Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0072089	stem cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000043
GO:0005635	nuclear envelope	Cellular Component	IEA	GO_REF:0000044
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005109	frizzled binding	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:22575959
GO:0005515	protein binding	Molecular Function	IPI	PMID:18313049

Enzyme–Substrate Interactions ▾


Q68DV7	RNF43	Yes	Yes	No	No	18313049	EBI-1647320	E3-specific
Q9ULX6	AKP8L	Yes	Yes	Yes	No	18313049	EBI-1647059	E3-specific
Q13467	FZD5	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
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Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q68DV7	RNF43	Yes	Yes	No	No	18313049	EBI-1647320	E3-specific
Q9ULX6	AKP8L	Yes	Yes	Yes	No	18313049	EBI-1647059	E3-specific
Q13467	FZD5	Yes	Yes	No	No	—	No	E3-specific