E4F1

Details:

UniProt Entry: Q66K89
Gene: E4F1
Class: RING
Family: RING6
Protein length: 784
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q66K89
MEGAMAVRVT AAHTAEAQAE AGREAGEGAV AAVAAALAPS GFLGLPAPFS EEDEDDVHRC
GRCQAEFTAL EDFVQHKIQK ACQRAPPEAL PATPATTALL GQEVVPAAPG PEEPITVAHI
VVEAASLAAD ISHASDLVGG GHIKEVIVAA EAELGDGEMA EAPGSPRQQG LGLAGEGEQA
QVKLLVNKDG RYVCALCHKT FKTGSILKAH MVTHSSRKDH ECKLCGASFR TKGSLIRHHR
RHTDERPYKC SKCGKSFRES GALTRHLKSL TPCTEKIRFS VSKDVVVSKE DARAGSGAGA
AGLGTATSSV TGEPIETSPV IHLVTDAKGT VIHEVHVQMQ ELSLGMKALA PEPPVSQELP
CSSEGSRENL LHQAMQNSGI VLERAAGEEG ALEPAPAAGS SPQPLAVAAP QLPVLEVQPL
ETQVASEASA VPRTHPCPQC SETFPTAATL EAHKRGHTGP RPFACAQCGK AFPKAYLLKK
HQEVHVRERR FRCGDCGKLY KTIAHVRGHR RVHSDERPYP CPKCGKRYKT KNAQQVHFRT
HLEEKPHVCQ FCSRGFREKG SLVRHVRHHT GEKPFKCYKC GRGFAEHGTL NRHLRTKGGC
LLEVEELLVS EDSPAAATTV LTEDPHTVLV EFSSVVADTQ EYIIEATADD AETSEATEII
EGTQTEVDSH IMKVVQQIVH QASAGHQIIV QNVTMDEETA LGPEAAAADT ITIATPESLT
EQVAMTLASA ISEGTVLAAR AGTSGTEQAT VTMVSSEDIE ILEHAGELVI ASPEGQLEVQ
TVIV

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
58	78	Domain	Zinc finger C2H2-type	IPR013087	SM00355
190	231	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
192	214	Domain	Zinc finger C2H2-type	IPR013087	SM00355
192	219	Domain	Zinc finger C2H2-type	IPR013087	PS50157
194	214	Domain	Zinc finger C2H2-type	IPR013087	PS00028
218	268	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
220	242	Domain	Zinc finger C2H2-type	IPR013087	SM00355
220	242	Domain	Zinc finger C2H2-type	IPR013087	PF00096
220	247	Domain	Zinc finger C2H2-type	IPR013087	PS50157
222	242	Domain	Zinc finger C2H2-type	IPR013087	PS00028
248	268	Domain	Zinc finger C2H2-type	IPR013087	SM00355
248	268	Domain	Zinc finger C2H2-type	IPR013087	PF00096
248	277	Domain	Zinc finger C2H2-type	IPR013087	PS50157
435	457	Domain	Zinc finger C2H2-type	IPR013087	SM00355
435	462	Domain	Zinc finger C2H2-type	IPR013087	PS50157
435	457	Domain	Zinc finger C2H2-type	IPR013087	PF00096
437	457	Domain	Zinc finger C2H2-type	IPR013087	PS00028
443	499	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
463	485	Domain	Zinc finger C2H2-type	IPR013087	PF00096
463	490	Domain	Zinc finger C2H2-type	IPR013087	PS50157
463	485	Domain	Zinc finger C2H2-type	IPR013087	SM00355
465	485	Domain	Zinc finger C2H2-type	IPR013087	PS00028
488	529	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
491	518	Domain	Zinc finger C2H2-type	IPR013087	PS50157
491	513	Domain	Zinc finger C2H2-type	IPR013087	SM00355
493	513	Domain	Zinc finger C2H2-type	IPR013087	PS00028
519	546	Domain	Zinc finger C2H2-type	IPR013087	PS50157
519	541	Domain	Zinc finger C2H2-type	IPR013087	SM00355
519	541	Domain	Zinc finger C2H2-type	IPR013087	PF00096
521	541	Domain	Zinc finger C2H2-type	IPR013087	PS00028
528	584	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
547	569	Domain	Zinc finger C2H2-type	IPR013087	SM00355
547	574	Domain	Zinc finger C2H2-type	IPR013087	PS50157
549	569	Domain	Zinc finger C2H2-type	IPR013087	PS00028
575	595	Domain	Zinc finger C2H2-type	IPR013087	SM00355
575	599	Domain	Zinc finger C2H2-type	IPR013087	PS50157

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IEA	GO_REF:0000117
GO:0010564	regulation of cell cycle process	Biological Process	IEA	GO_REF:0000117
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000043
GO:0006260	DNA replication	Biological Process	IEA	GO_REF:0000107
GO:0009794	regulation of mitotic cell cycle, embryonic	Biological Process	IEA	GO_REF:0000107
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:14645522
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0051726	regulation of cell cycle	Biological Process	TAS	PMID:14645522
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0016604	nuclear body	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000107
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Molecular Function	IDA	PMID:2169022
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:16652157
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Molecular Function	IDA	PMID:10869426
GO:0003700	DNA-binding transcription factor activity	Molecular Function	IBA	GO_REF:0000033
GO:0035497	cAMP response element binding	Molecular Function	IDA	PMID:14645522
GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Molecular Function	IPI	PMID:14645522
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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