DCA15

Details:

UniProt Entry: Q66K64
Gene: DCAF15
Class: Other E3 Components
Family: Adaptor
Protein length: 600
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q66K64
MAPSSKSERN SGAGSGGGGP GGAGGKRAAG RRREHVLKQL ERVKISGQLS PRLFRKLPPR
VCVSLKNIVD EDFLYAGHIF LGFSKCGRYV LSYTSSSGDD DFSFYIYHLY WWEFNVHSKL
KLVRQVRLFQ DEEIYSDLYL TVCEWPSDAS KVIVFGFNTR SANGMLMNMM MMSDENHRDI
YVSTVAVPPP GRCAACQDAS RAHPGDPNAQ CLRHGFMLHT KYQVVYPFPT FQPAFQLKKD
QVVLLNTSYS LVACAVSVHS AGDRSFCQIL YDHSTCPLAP ASPPEPQSPE LPPALPSFCP
EAAPARSSGS PEPSPAIAKA KEFVADIFRR AKEAKGGVPE EARPALCPGP SGSRCRAHSE
PLALCGETAP RDSPPASEAP ASEPGYVNYT KLYYVLESGE GTEPEDELED DKISLPFVVT
DLRGRNLRPM RERTAVQGQY LTVEQLTLDF EYVINEVIRH DATWGHQFCS FSDYDIVILE
VCPETNQVLI NIGLLLLAFP SPTEEGQLRP KTYHTSLKVA WDLNTGIFET VSVGDLTEVK
GQTSGSVWSS YRKSCVDMVM KWLVPESSGR YVNRMTNEAL HKGCSLKVLA DSERYTWIVL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	600	Family	DDB1- and CUL4-associated factor 15	IPR038914	PTHR28541
50	259	Domain	DDB1- and CUL4-associated factor 15, WD40 repeat-containing domain	IPR032734	PF14939

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:28302793
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0032814	regulation of natural killer cell activation	Biological Process	IMP	PMID:31452512
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16949367
GO:0036094	small molecule binding	Molecular Function	IPI	PMID:28302793
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Handle	—	PROTACDB3	6.0*	EF6	—	NS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)c[nH]c23)cc1

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