FBXW9

Details:

UniProt Entry: Q5XUX1
Gene: FBXW9
Class: Other E3 Components
Family: Receptor
Protein length: 458
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q5XUX1
MELPLGRCDD SRTWDDDSDP ESETDPDAQA KAYVARVLSP PKSGLAFSRP SQLSTPAASP
SASEPRAASR VSAVSEPGLL SLPPELLLEI CSYLDARLVL HVLSRVCHAL RDLVSDHVTW
RLRALRRVRA PYPVVEEKNF DWPAACIALE QHLSRWAEDG RWVEYFCLAE GHVASVDSVL
LLQGGSLCLS GSRDRNVNLW DLRQLGTESN QVLIKTLGTK RNSTHEGWVW SLAAQDHRVC
SGSWDSTVKL WDMAADGQQF GEIKASSAVL CLSYLPDILV TGTYDKKVTI YDPRAGPALL
KHQQLHSRPV LTLLADDRHI ISGSEDHTLV VVDRRANSVL QRLQLDSYLL CMSYQEPQLW
AGDNQGLLHV FANRNGCFQL IRSFDVGHSF PITGIQYSVG ALYTTSTDKT IRVHVPTDPP
RTICTRRHDN GLNRVCAEGN LVVAGSGDLS LEVWRLQA

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
69	136	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
76	123	Domain	F-box domain	IPR001810	PS50181
80	121	Domain	F-box domain	IPR001810	PF12937
82	123	Domain	F-box domain	IPR001810	SM00256
131	342	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
161	201	Repeat	WD40 repeat	IPR001680	SM00320
168	456	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
169	203	Repeat	WD40 repeat	IPR001680	PS50082
170	201	Repeat	WD40 repeat	IPR001680	PF00400
188	202	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
188	202	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
210	252	Repeat	WD40 repeat	IPR001680	SM00320
222	253	Repeat	WD40 repeat	IPR001680	PS50082
223	252	Repeat	WD40 repeat	IPR001680	PF00400
239	253	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320
239	253	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
256	292	Repeat	WD40 repeat	IPR001680	SM00320
296	333	Repeat	WD40 repeat	IPR001680	SM00320
343	458	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
377	415	Repeat	WD40 repeat	IPR001680	SM00320
419	455	Repeat	WD40 repeat	IPR001680	SM00320
438	458	Repeat	WD40 repeat	IPR001680	PS50082
442	456	Repeat	G-protein beta WD-40 repeat	IPR020472	PR00320

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0005515	protein binding	Molecular Function	IPI	PMID:19159283

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.