FBX31

Details:

UniProt Entry: Q5XUX0
Gene: FBXO31
Class: Other E3 Components
Family: Receptor
Protein length: 539
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q5XUX0
MAVCARLCGV GPSRGCRRRQ QRRGPAETAA ADSEPDTDPE EERIEASAGV GGGLCAGPSP
PPPRCSLLEL PPELLVEIFA SLPGTDLPSL AQVCTKFRRI LHTDTIWRRR CREEYGVCEN
LRKLEITGVS CRDVYAKLLH RYRHILGLWQ PDIGPYGGLL NVVVDGLFII GWMYLPPHDP
HVDDPMRFKP LFRIHLMERK AATVECMYGH KGPHHGHIQI VKKDEFSTKC NQTDHHRMSG
GRQEEFRTWL REEWGRTLED IFHEHMQELI LMKFIYTSQY DNCLTYRRIY LPPSRPDDLI
KPGLFKGTYG SHGLEIVMLS FHGRRARGTK ITGDPNIPAG QQTVEIDLRH RIQLPDLENQ
RNFNELSRIV LEVRERVRQE QQEGGHEAGE GRGRQGPRES QPSPAQPRAE APSKGPDGTP
GEDGGEPGDA VAAAEQPAQC GQGQPFVLPV GVSSRNEDYP RTCRMCFYGT GLIAGHGFTS
PERTPGVFIL FDEDRFGFVW LELKSFSLYS RVQATFRNAD APSPQAFDEM LKNIQSLTS

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
38	538	Family	F-box only protein 31/39	IPR045048	PTHR10706
56	138	Homologous_superfamily	F-box-like domain superfamily	IPR036047	SSF81383
64	110	Domain	F-box domain	IPR001810	PS50181
68	112	Domain	F-box domain	IPR001810	PF12937
70	110	Domain	F-box domain	IPR001810	SM00256

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0030330	DNA damage response, signal transduction by p53 class mediator	Biological Process	IDA	PMID:29681526
GO:0038066	p38MAPK cascade	Biological Process	IDA	PMID:10330143
GO:0042770	signal transduction in response to DNA damage	Biological Process	IDA	PMID:24936062
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:29681526
GO:1901797	negative regulation of signal transduction by p53 class mediator	Biological Process	IDA	PMID:29681526
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	IMP	PMID:19412162
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0031571	mitotic G1 DNA damage checkpoint signaling	Biological Process	IMP	PMID:19412162
GO:0034599	cellular response to oxidative stress	Biological Process	IDA	PMID:39880951
GO:0005737	cytoplasm	Cellular Component	IDA	PMID:24828503
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-8952618
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0043025	neuronal cell body	Cellular Component	ISS	GO_REF:0000024
GO:0019005	SCF ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:19412162
GO:0030332	cyclin binding	Molecular Function	IPI	PMID:19412162
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:19412162

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