UBE2U

Details:

UniProt Entry: Q5VVX9
Gene: UBE2U
Class: Other E3 Components
Family: E2
Protein length: 321
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q5VVX9
MHGRAYLLLH RDFCDLKENN YKGITAKPVS EDMMEWEVEI EGLQNSVWQG LVFQLTIHFT
SEYNYAPPVV KFITIPFHPN VDPHTGQPCI DFLDNPEKWN TNYTLSSILL ALQVMLSNPV
LENPVNLEAA RILVKDESLY RTILRLFNRP LQMKDDSQEL PKDPRKCIRP IKTTSFSDYY
QTWSRIATSK ATEYYRTPLL KVPNFIGQYY KWKKMDLQHQ KEWNLKYSVI KCWLARKRMP
HEVTHSMEEI KLCPTLIPTT DEIFLESPTA INSITDIYET EEEGWKSDTS LYENDTDEPR
EEEVEDLISW TNTLNTNTSE D

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	149	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
1	146	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
4	153	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
8	147	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	cd00195
9	144	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179
77	93	Active_site	Ubiquitin-conjugating enzyme, active site	IPR023313	PS00183

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0032446	protein modification by small protein conjugation	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0006281	DNA repair	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0033503	HULC complex	Cellular Component	IBA	GO_REF:0000033
GO:0000166	nucleotide binding	Molecular Function	IEA	GO_REF:0000043
GO:0005524	ATP binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0019787	ubiquitin-like protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0061631	ubiquitin conjugating enzyme activity	Molecular Function	IEA	GO_REF:0000003

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