BRE1A

Details:

UniProt Entry: Q5VTR2
Gene: RNF20
Class: RING
Family: RING9
Protein length: 975
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 5trb

Protein Sequence ▾

>Q5VTR2
MSGIGNKRAA GEPGTSMPPE KKAAVEDSGT TVETIKLGGV SSTEELDIRT LQTKNRKLAE
MLDQRQAIED ELREHIEKLE RRQATDDASL LIVNRYWSQF DENIRIILKR YDLEQGLGDL
LTERKALVVP EPEPDSDSNQ ERKDDRERGE GQEPAFSFLA TLASSSSEEM ESQLQERVES
SRRAVSQIVT VYDKLQEKVE LLSRKLNSGD NLIVEEAVQE LNSFLAQENM RLQELTDLLQ
EKHRTMSQEF SKLQSKVETA ESRVSVLESM IDDLQWDIDK IRKREQRLNR HLAEVLERVN
SKGYKVYGAG SSLYGGTITI NARKFEEMNA ELEENKELAQ NRLCELEKLR QDFEEVTTQN
EKLKVELRSA VEQVVKETPE YRCMQSQFSV LYNESLQLKA HLDEARTLLH GTRGTHQHQV
ELIERDEVSL HKKLRTEVIQ LEDTLAQVRK EYEMLRIEFE QTLAANEQAG PINREMRHLI
SSLQNHNHQL KGEVLRYKRK LREAQSDLNK TRLRSGSALL QSQSSTEDPK DEPAELKPDS
EDLSSQSSAS KASQEDANEI KSKRDEEERE RERREKERER EREREKEKER EREKQKLKES
EKERDSAKDK EKGKHDDGRK KEAEIIKQLK IELKKAQESQ KEMKLLLDMY RSAPKEQRDK
VQLMAAEKKS KAELEDLRQR LKDLEDKEKK ENKKMADEDA LRKIRAVEEQ IEYLQKKLAM
AKQEEEALLS EMDVTGQAFE DMQEQNIRLM QQLREKDDAN FKLMSERIKS NQIHKLLKEE
KEELADQVLT LKTQVDAQLQ VVRKLEEKEH LLQSNIGTGE KELGLRTQAL EMNKRKAMEA
AQLADDLKAQ LELAQKKLHD FQDEIVENSV TKEKDMFNFK RAQEDISRLR RKLETTKKPD
NVPKCDEILM EEIKDYKARL TCPCCNMRKK DAVLTKCFHV FCFECVKTRY DTRQRKCPKC
NAAFGANDFH RIYIG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
579	974	Family	E3 ubiquitin ligase Bre1	IPR013956	PTHR23163
903	975	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
922	960	Domain	Zinc finger, RING-type	IPR001841	SM00184
922	961	Domain	Zinc finger, RING-type	IPR001841	PS50089
922	960	Domain	Zinc finger, C3HC4 RING-type	IPR018957	PF00097
937	946	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006325	chromatin organization	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0007346	regulation of mitotic cell cycle	Biological Process	IMP	PMID:19575011
GO:0000209	protein polyubiquitination	Biological Process	IDA	PMID:19037095
GO:0006338	chromatin remodeling	Biological Process	IEA	GO_REF:0000108
GO:0006355	regulation of DNA-templated transcription	Biological Process	IMP	PMID:18832071
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:19037095
GO:0030336	negative regulation of cell migration	Biological Process	IDA	PMID:18832071
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IMP	PMID:16713563
GO:0045944	positive regulation of transcription by RNA polymerase II	Biological Process	IDA	PMID:16307923
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	PMID:19037095
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA	PMID:16307923
GO:0033503	HULC complex	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0002039	p53 binding	Molecular Function	IDA	PMID:16337599
GO:0003682	chromatin binding	Molecular Function	IEA	GO_REF:0000107
GO:0003713	transcription coactivator activity	Molecular Function	IDA	PMID:16337599
GO:0003730	mRNA 3'-UTR binding	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:16307923
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI	PMID:16307923
GO:0042393	histone binding	Molecular Function	IDA	PMID:16337599
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:32296183
GO:0140850	histone H2B C-terminal K residue ubiquitin ligase activity	Molecular Function	IEA	GO_REF:0000120

Enzyme–Substrate Interactions ▾


P62807	H2B1C	Yes	Yes	No	No	—	No	Cluster-specific

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