RN220

Details:

UniProt Entry: Q5VTB9
Gene: RNF220
Class: RING
Family: RING9
Protein length: 566
Database confidence: 1.0
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q5VTB9
MDLHRAAFKM ENSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV PVSVDKDVHI
PFTNGSYTFA SMYHRQGGVP GTFANRDFPP SLLHLHPQFA PPNLDCTPIS MLNHSGVGAF
RPFASTEDRE SYQSAFTPAK RLKNCHDTES PHLRFSDADG KEYDFGTQLP SSSPGSLKVD
DTGKKIFAVS GLISDREASS SPEDRNDRCK KKAAALFDSQ APICPICQVL LRPSELQEHM
EQELEQLAQL PSSKNSLLKD AMAPGTPKSL LLSASIKREG ESPTASPHSS ATDDLHHSDR
YQTFLRVRAN RQTRLNARIG KMKRRKQDEG QREGSCMAED DAVDIEHENN NRFEEYEWCG
QKRIRATTLL EGGFRGSGFI MCSGKENPDS DADLDVDGDD TLEYGKPQYT EADVIPCTGE
EPGEAKEREA LRGAVLNGGP PSTRITPEFS KWASDEMPST SNGESSKQEA MQKTCKNSDI
EKITEDSAVT TFEALKARVR ELERQLSRGD RYKCLICMDS YSMPLTSIQC WHVHCEECWL
RTLGAKKLCP QCNTITAPGD LRRIYL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
217	337	Domain	E3 ubiquitin-protein ligase RNF220, middle domain	IPR031824	PF15926
339	443	Domain	E3 ubiquitin-protein ligase RNF220, middle domain	IPR031824	PF15926
495	566	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
513	553	Domain	E3 ubiquitin-protein ligase RNF220, RING finger	IPR040178	cd16563
514	553	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0003358	noradrenergic neuron development	Biological Process	IEA	GO_REF:0000107
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0021904	dorsal/ventral neural tube patterning	Biological Process	IEA	GO_REF:0000107
GO:0051091	positive regulation of DNA-binding transcription factor activity	Biological Process	IGI	PMID:32094113
GO:2000677	regulation of transcription regulatory region DNA binding	Biological Process	IGI	PMID:32094113
GO:0016567	protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0090263	positive regulation of canonical Wnt signaling pathway	Biological Process	IMP	PMID:25266658
GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	Biological Process	IEA	GO_REF:0000107
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0098794	postsynapse	Cellular Component	IEA	GO_REF:0000107
GO:0098978	glutamatergic synapse	Cellular Component	IEA	GO_REF:0000107
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005652	nuclear lamina	Cellular Component	IMP	PMID:33964137
GO:0005737	cytoplasm	Cellular Component	ISS	GO_REF:0000024
GO:0032991	protein-containing complex	Cellular Component	IDA	PMID:30177510
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:19549727
GO:0008013	beta-catenin binding	Molecular Function	IMP	PMID:33964137
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q96ST3	SIN3A	Yes	No	No	No	—	No	E3-specific
O75182	SIN3B	Yes	Yes	No	No	—	No	E3-specific
Q5VTB9	RN220	Yes	Yes	No	No	—	No	E3-specific

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If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q96ST3	SIN3A	Yes	No	No	No	—	No	E3-specific
O75182	SIN3B	Yes	Yes	No	No	—	No	E3-specific
Q5VTB9	RN220	Yes	Yes	No	No	—	No	E3-specific