RC3H1

>Q5TC82
MPVQAPQWTD FLSCPICTQT FDETIRKPIS LGCGHTVCKM CLNKLHRKAC PFDQTTINTD
IELLPVNSAL LQLVGAQVPE QQPITLCSGV EDTKHYEEAK KCVEELALYL KPLSSARGVG
LNSTTQSVLS RPMQRKLVTL VHCQLVEEEG RIRAMRAARS LGERTVTELI LQHQNPQQLS
SNLWAAVRAR GCQFLGPAMQ EEALKLVLLA LEDGSALSRK VLVLFVVQRL EPRFPQASKT
SIGHVVQLLY RASCFKVTKR DEDSSLMQLK EEFRTYEALR REHDSQIVQI AMEAGLRIAP
DQWSSLLYGD QSHKSHMQSI IDKLQTPASF AQSVQELTIA LQRTGDPANL NRLRPHLELL
ANIDPSPDAP PPTWEQLENG LVAVRTVVHG LVDYIQNHSK KGADQQQPPQ HSKYKTYMCR
DMKQRGGCPR GASCTFAHSQ EELEKFRKMN KRLVPRRPLS ASLGQLNEVG LPSAAILPDE
GAVDLPSRKP PALPNGIVST GNTVTQLIPR GTDPSYDSSL KPGKIDHLSS SAPGSPPDLL
ESVPKSISAL PVNPHSIPPR GPADLPPMPV TKPLQMVPRG SQLYPAQQTD VYYQDPRGAA
PPFEPAPYQQ GMYYTPPPQC VSRFVRPPPS APEPAPPYLD HYPPYLQERV VNSQYGTQPQ
QYPPIYPSHY DGRRVYPAPS YTREEIFRES PIPIEIPPAA VPSYVPESRE RYQQIESYYP
VAPHPTQIRP SYLREPPYSR LPPPPQPHPS LDELHRRRKE IMAQLEERKV ISPPPFAPSP
TLPPTFHPEE FLDEDLKVAG KYKGNDYSQY SPWSCDTIGS YIGTKDAKPK DVVAAGSVEM
MNVESKGMRD QRLDLQRRAA ETSDDDLIPF GDRPTVSRFG AISRTSKTIY QGAGPMQAMA
PQGAPTKSIN ISDYSPYGTH GGWGASPYSP HQNIPSQGHF SERERISMSE VASHGKPLPS
AEREQLRLEL QQLNHQISQQ TQLRGLEAVS NRLVLQREAN TLAGQSQPPP PPPPKWPGMI
SSEQLSLELH QVEREIGKRT RELSMENQCS LDMKSKLNTS KQAENGQPEP QNKVPAEDLT
LTFSDVPNGS ALTQENISLL SNKTSSLNLS EDPEGGGDNN DSQRSGVTPS SAP

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
3	82	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
14	53	Domain	Zinc finger, RING-type	IPR001841	SM00184
14	43	Domain	Zinc finger, RING-type, eukaryotic	IPR027370	PF13445
14	54	Domain	Zinc finger, RING-type	IPR001841	PS50089
33	42	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
271	326	Domain	Roquin II	IPR041523	PF18386
411	444	Homologous_superfamily	Zinc finger, CCCH-type superfamily	IPR036855	SSF90229
413	440	Domain	Zinc finger, CCCH-type	IPR000571	SM00356
413	441	Domain	Zinc finger, CCCH-type	IPR000571	PS50103

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0001782	B cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0010468	regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010608	post-transcriptional regulation of gene expression	Biological Process	IEA	GO_REF:0000107
GO:0042098	T cell proliferation	Biological Process	IEA	GO_REF:0000107
GO:0043029	T cell homeostasis	Biological Process	IEA	GO_REF:0000107
GO:0045623	negative regulation of T-helper cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0048535	lymph node development	Biological Process	IEA	GO_REF:0000107
GO:0048536	spleen development	Biological Process	IEA	GO_REF:0000107
GO:0061470	T follicular helper cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:1901224	positive regulation of non-canonical NF-kappaB signal transduction	Biological Process	IEA	GO_REF:0000107
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	Biological Process	ISS	GO_REF:0000024
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process	IBA	GO_REF:0000033
GO:0000956	nuclear-transcribed mRNA catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0002634	regulation of germinal center formation	Biological Process	ISS	GO_REF:0000024
GO:0002635	negative regulation of germinal center formation	Biological Process	ISS	GO_REF:0000024
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0030889	negative regulation of B cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0033962	P-body assembly	Biological Process	ISS	GO_REF:0000024
GO:0043488	regulation of mRNA stability	Biological Process	ISS	GO_REF:0000024
GO:0046007	negative regulation of activated T cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0050852	T cell receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0050856	regulation of T cell receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0061014	positive regulation of mRNA catabolic process	Biological Process	IEA	GO_REF:0000107
GO:0061158	3'-UTR-mediated mRNA destabilization	Biological Process	ISS	GO_REF:0000024
GO:0071347	cellular response to interleukin-1	Biological Process	ISS	GO_REF:0000024
GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process	IMP	PMID:31636267
GO:2000320	negative regulation of T-helper 17 cell differentiation	Biological Process	ISS	GO_REF:0000024
GO:2000628	regulation of miRNA metabolic process	Biological Process	ISS	GO_REF:0000024
GO:0000932	P-body	Cellular Component	IEA	GO_REF:0000044
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0010494	cytoplasmic stress granule	Cellular Component	IBA	GO_REF:0000033
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003725	double-stranded RNA binding	Molecular Function	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0035613	RNA stem-loop binding	Molecular Function	IEA	GO_REF:0000117
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003
GO:0003729	mRNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0003730	mRNA 3'-UTR binding	Molecular Function	ISS	GO_REF:0000024
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:26489670
GO:0005515	protein binding	Molecular Function	IPI	PMID:25697406
GO:0035198	miRNA binding	Molecular Function	ISS	GO_REF:0000024
GO:1905762	CCR4-NOT complex binding	Molecular Function	IMP	PMID:31636267

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
Q9Y6W8	ICOS	Yes	Yes	No	No	—	No	E3-specific