ZBT37

Details:

UniProt Entry: Q5TC79
Gene: ZBTB37
Class: RING
Family: RING6
Protein length: 503
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link

Protein Sequence ▾

>Q5TC79
MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH
MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ
ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA
VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL
GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR
PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVEESAMMGV SGYVEYLREQ
EVSERWFRYN PRLTCIYCAK SFNQKGSLDR HMRLHMGITP FVCRMCGKKY TRKDQLEYHI
RKHTGNKPFH CHVCGKSFPF QAILNQHFRK NHPGCIPLEG PHSISPETTV TSRGQAEEES
PSQEETVAPG EAVQGSVSTT GPD

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
5	149	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
8	122	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
22	123	Domain	BTB/POZ domain	IPR000210	PF00651
32	96	Domain	BTB/POZ domain	IPR000210	PS50097
32	126	Domain	BTB/POZ domain	IPR000210	SM00225
373	400	Domain	Zinc finger C2H2-type	IPR013087	PS50157
373	395	Domain	Zinc finger C2H2-type	IPR013087	SM00355
374	403	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
374	395	Domain	Zinc finger C2H2-type	IPR013087	PF00096
375	395	Domain	Zinc finger C2H2-type	IPR013087	PS00028
395	447	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
401	423	Domain	Zinc finger C2H2-type	IPR013087	SM00355
401	428	Domain	Zinc finger C2H2-type	IPR013087	PS50157
401	423	Domain	Zinc finger C2H2-type	IPR013087	PF00096
403	423	Domain	Zinc finger C2H2-type	IPR013087	PS00028
429	452	Domain	Zinc finger C2H2-type	IPR013087	SM00355
429	457	Domain	Zinc finger C2H2-type	IPR013087	PS50157
431	452	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0000785	chromatin	Cellular Component	ISA	GO_REF:0000113
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Molecular Function	ISA	GO_REF:0000113
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:1990837	sequence-specific double-stranded DNA binding	Molecular Function	IDA	PMID:28473536

Enzyme–Substrate Interactions ▾

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