RN187

Details:

UniProt Entry: Q5TA31
Gene: RNF187
Class: RING
Family: RING4
Protein length: 235
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link
PDB Structures: 7ow2

Protein Sequence ▾

>Q5TA31
MALPAGPAEA ACALCQRAPR EPVRADCGHR FCRACVVRFW AEEDGPFPCP ECADDCWQRA
VEPGRPPLSR RLLALEEAAA APARDGPASE AALQLLCRAD AGPLCAACRM AAGPEPPEWE
PRWRKALRGK ENKGSVEIMR KDLNDARDLH GQAESAAAVW KGHVMDRRKK ALTDYKKLRA
FFVEEEEHFL QEAEKEEGLP EDELADPTER FRSLLQAVSE LEKKHRNLGL SMLLQ

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	114	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
12	52	Domain	Zinc finger, RING-type	IPR001841	SM00184
12	52	Domain	Zinc finger, RING-type	IPR001841	PS50089
27	36	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0008284	positive regulation of cell population proliferation	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:20852630
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	IMP	PMID:20852630
GO:0051865	protein autoubiquitination	Biological Process	IDA	PMID:20852630
GO:0070936	protein K48-linked ubiquitination	Biological Process	IMP	PMID:20852630
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IDA	PMID:20852630
GO:0005515	protein binding	Molecular Function	IPI	PMID:20852630
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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