DCST1

Details:

UniProt Entry: Q5T197
Gene: DCST1
Class: RING
Family: RING9
Protein length: 706
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q5T197
MDIKHHQNGT RGQRRKQPHT TVQRLLTWGL PVSCSWFLWR QPGEFPVTAL LLGAGAGGLL
AIGLFQLLVN PMNIYEEQKI MFLYSLVGLG AMGWGTSPHI RCASLLLVPK MLGKEGRLFV
LGYALAAIYV GPVANLRHNL NNVIASLGCT VELQINNTRA AWRISTAPLR AMFKDLLSSK
ELLRAETRNI SATFEDLDAQ VNSETGYTPE DTMDSGETAQ GREARQAPAS RLHLSTQKMY
ELKTKLRCSY VVNQAILSCR RWFDRKHEQC MKHIWVPLLT HLLCLPMKFK FFCGIAKVME
VWCRNRIPVE GNFGQTYDSL NQSIRGLDGE FSANIDFKEE KQAGVLGLNT SWERVSTEVR
DYVYRQEARL EWALGLLHVL LSCTFLLVLH ASFSYMDSYN HDIRFDNIYI STYFCQIDDR
RKKLGKRTLL PLRKAEEKTV IFPCKPTIQA SEMSNVVREL LETLPILLLL VVLCGLDWAL
YSIFDTIRHH SFLQYSFRSS HKLEVKVGGD SMLARLLRKT IGALNTSSET VMESNNMPCL
PQPVGLDARA YWRAAVPIGL LVCLCLLQAF GYRLRRVIAA FYFPKREKKR ILFLYNDLLK
KRAAFTKLRR AAILRRERQQ KAPRHPLADI LHRGCPLLRR WLCRRCVVCQ APETPESYVC
RTLDCEAVYC WSCWDDMRQR CPVCTPREEL SSSAFSDSND DTAYAG

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
405	595	Domain	Dendritic cell-specific transmembrane protein-like	IPR012858	PF07782
646	685	Domain	Zinc finger, RING-type	IPR001841	PS50089

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IMP	PMID:27782195
GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0035036	sperm-egg recognition	Biological Process	ISS	GO_REF:0000024
GO:0045087	innate immune response	Biological Process	IEA	GO_REF:0000043
GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Biological Process	IMP	PMID:27782195
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0002080	acrosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005886	plasma membrane	Cellular Component	IEA	GO_REF:0000120
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:27782195
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾

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