MARH8

>Q5T0T0
MSMPLHQISA IPSQDAISAR VYRSKTKEKE REEQNEKTLG HFMSHSSNIS KAGSPPSASA
PAPVSSFSRT SITPSSQDIC RICHCEGDDE SPLITPCHCT GSLHFVHQAC LQQWIKSSDT
RCCELCKYEF IMETKLKPLR KWEKLQMTSS ERRKIMCSVT FHVIAITCVV WSLYVLIDRT
AEEIKQGQAT GILEWPFWTK LVVVAIGFTG GLLFMYVQCK VYVQLWKRLK AYNRVIYVQN
CPETSKKNIF EKSPLTEPNF ENKHGYGICH SDTNSSCCTE PEDTGAEIIH V

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
64	142	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
72	133	Domain	Zinc finger, RING-CH-type	IPR011016	PS51292
79	127	Domain	Zinc finger, RING-CH-type	IPR011016	SM00744
80	126	Domain	Zinc finger, RING-CH-type	IPR011016	PF12906
80	127	Domain	Zinc finger, RING-type	IPR001841	PS50089

GO term	Name	Ontology	Evidence	Reference
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0002250	adaptive immune response	Biological Process	IEA	GO_REF:0000043
GO:0002376	immune system process	Biological Process	IEA	GO_REF:0000043
GO:0002495	antigen processing and presentation of peptide antigen via MHC class II	Biological Process	IBA	GO_REF:0000033
GO:0006955	immune response	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000120
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005764	lysosome	Cellular Component	IBA	GO_REF:0000033
GO:0031901	early endosome membrane	Cellular Component	IBA	GO_REF:0000033
GO:0031902	late endosome membrane	Cellular Component	IBA	GO_REF:0000033
GO:0000139	Golgi membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005765	lysosomal membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005768	endosome	Cellular Component	IEA	GO_REF:0000043
GO:0005783	endoplasmic reticulum	Cellular Component	IEA	GO_REF:0000043
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IEA	GO_REF:0000044
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000043
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	IEA	GO_REF:0000044
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0042287	MHC protein binding	Molecular Function	IBA	GO_REF:0000033
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Substrate	Name	Known ESI (UbiBrowser)	Known ESI (UbiNet)	PPI (IntAct direct) PSI-MI score ≥ 0.5	PPI (IntAct indirect) PSI-MI scores ≥ 0.5 for both PPIs	PubMed Ref.	IntAct Ref.	Substrate Specificity
P08195	4F2	Yes	Yes	No	No	—	No	E3-specific
Q9NZQ7	PD1L1	Yes	No	No	No	—	No	E3-specific
P49327	FAS	Yes	Yes	No	No	—	No	Cluster-specific
P02786	TFR1	Yes	Yes	No	No	—	No	Cluster-specific
P01023	A2MG	Yes	No	No	No	—	No	E3-specific
P33076	C2TA	Yes	Yes	No	No	—	No	Cluster-specific
P42081	CD86	Yes	Yes	No	No	—	No	Cluster-specific
P04233	HG2A	Yes	Yes	No	No	—	No	E3-specific
P01911	DRB1	Yes	Yes	No	No	—	No	Cluster-specific
Q30154	DRB5	Yes	Yes	No	No	—	No	Cluster-specific
P13762	DRB4	Yes	Yes	No	No	—	No	Cluster-specific
P79483	DRB3	Yes	Yes	No	No	—	No	Cluster-specific
Q9NPH3	IL1AP	Yes	Yes	No	No	—	No	E3-specific
P01903	DRA	Yes	Yes	No	No	—	No	Cluster-specific