HERC4

Details:

UniProt Entry: Q5GLZ8
Gene: HERC4
Class: HECT
Family: HECT1
Protein length: 1057
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q5GLZ8
MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLVG
SEECIRVPRN IKSLSDIQIV QVACGYYHSL ALSKASEVFC WGQNKYGQLG LGTDCKKQTS
PQLLKSLLGI PFMQVAAGGA HSFVLTLSGA IFGWGRNKFG QLGLNDENDR YVPNLLKSLR
SQKIVYICCG EDHTAALTKE GGVFTFGAGG YGQLGHNSTS HEINPRKVFE LMGSIVTEIA
CGRQHTSAFV PSSGRIYSFG LGGNGQLGTG STSNRKSPFT VKGNWYPYNG QCLPDIDSEE
YFCVKRIFSG GDQSFSHYSS PQNCGPPDDF RCPNPTKQIW TVNEALIQKW LSYPSGRFPV
EIANEIDGTF SSSGCLNGSF LAVSNDDHYR TGTRFSGVDM NAARLLFHKL IQPDHPQISQ
QVAASLEKNL IPKLTSSLPD VEALRFYLTL PECPLMSDSN NFTTIAIPFG TALVNLEKAP
LKVLENWWSV LEPPLFLKIV ELFKEVVVHL LKLYKIGIPP SERRIFNSFL HTALKVLEIL
HRVNEKMGQI IQYDKFYIHE VQELIDIRND YINWVQQQAY GMDVNHGLTE LADIPVTICT
YPFVFDAQAK TTLLQTDAVL QMQMAIDQAH RQNVSSLFLP VIESVNPCLI LVVRRENIVG
DAMEVLRKTK NIDYKKPLKV IFVGEDAVDA GGVRKEFFLL IMRELLDPKY GMFRYYEDSR
LIWFSDKTFE DSDLFHLIGV ICGLAIYNCT IVDLHFPLAL YKKLLKKKPS LDDLKELMPD
VGRSMQQLLD YPEDDIEETF CLNFTITVEN FGATEVKELV LNGADTAVNK QNRQEFVDAY
VDYIFNKSVA SLFDAFHAGF HKVCGGKVLL LFQPNELQAM VIGNTNYDWK ELEKNTEYKG
EYWAEHPTIK IFWEVFHELP LEKKKQFLLF LTGSDRIPIL GMKSLKLVIQ STGGGEEYLP
VSHTCFNLLD LPKYTEKETL RSKLIQAIDH NEGFSLI

Domain Architecture (From InterPro) ▾

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
1	52	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
1	122	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
2	49	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
2	347	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
39	49	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
52	99	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
53	102	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
55	71	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
102	152	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
103	155	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
103	119	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
123	375	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
142	152	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
142	158	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
156	208	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
157	205	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
158	172	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
208	257	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
209	260	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
247	257	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
250	268	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
260	308	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
261	312	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
309	330	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
313	343	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
314	380	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
699	1051	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
709	1055	Domain	HECT domain	IPR000569	cd00078
728	1057	Domain	HECT domain	IPR000569	SM00119
730	1057	Domain	HECT domain	IPR000569	PS50237
760	1056	Domain	HECT domain	IPR000569	PF00632

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0007283	spermatogenesis	Biological Process	IEA	GO_REF:0000120
GO:0016567	protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0030154	cell differentiation	Biological Process	IEA	GO_REF:0000043
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	IMP	PMID:31010679
GO:0001650	fibrillar center	Cellular Component	IDA	GO_REF:0000052
GO:0005829	cytosol	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

Enzyme–Substrate Interactions ▾


O95835	LATS1	Yes	No	No	No	—	No	Cluster-specific

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