KLH22

Details:

UniProt Entry: Q53GT1
Gene: KLHL22
Class: Other E3 Components
Family: Adaptor
Protein length: 634
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q53GT1
MAEEQEFTQL CKLPAQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH
IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV
QETLVAACQL QIPEIIHFCC DFLMSWVDEE NILDVYRLAE LFDLSRLTEQ LDTYILKNFV
AFSRTDKYRQ LPLEKVYSLL SSNRLEVSCE TEVYEGALLY HYSLEQVQAD QISLHEPPKL
LETVRFPLME AEVLQRLHDK LDPSPLRDTV ASALMYHRNE SLQPSLQSPQ TELRSDFQCV
VGFGGIHSTP STVLSDQAKY LNPLLGEWKH FTASLAPRMS NQGIAVLNNF VYLIGGDNNV
QGFRAESRCW RYDPRHNRWF QIQSLQQEHA DLSVCVVGRY IYAVAGRDYH NDLNAVERYD
PATNSWAYVA PLKREVYAHA GATLEGKMYI TCGRRGEDYL KETHCYDPGS NTWHTLADGP
VRRAWHGMAT LLNKLYVIGG SNNDAGYRRD VHQVACYSCT SGQWSSVCPL PAGHGEPGIA
VLDNRIYVLG GRSHNRGSRT GYVHIYDVEK DCWEEGPQLD NSISGLAACV LTLPRSLLLE
PPRGTPDRSQ ADPDFASEVM SVSDWEEFDN SSED

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
9	597	Family	BTB-kelch protein	IPR017096	PIRSF037037
25	147	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
27	145	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
42	143	Domain	BTB/POZ domain	IPR000210	PF00651
50	117	Domain	BTB/POZ domain	IPR000210	PS50097
50	147	Domain	BTB/POZ domain	IPR000210	SM00225
147	250	Domain	Kelch-like protein 22, BACK domain	IPR030575	cd18461
152	258	Domain	BTB/Kelch-associated	IPR011705	SM00875
153	257	Domain	BTB/Kelch-associated	IPR011705	PF07707
286	597	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
299	590	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
299	349	Repeat	Kelch repeat type 1	IPR006652	SM00612
350	399	Repeat	Kelch repeat type 1	IPR006652	SM00612
392	432	Repeat	Kelch repeat type 1	IPR006652	PF01344
400	446	Repeat	Kelch repeat type 1	IPR006652	SM00612
447	493	Repeat	Kelch repeat type 1	IPR006652	SM00612
494	544	Repeat	Kelch repeat type 1	IPR006652	SM00612
537	578	Repeat	Kelch repeat type 1	IPR006652	PF01344
545	593	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0002841	negative regulation of T cell mediated immune response to tumor cell	Biological Process	IDA	PMID:38377992
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:17636018
GO:0031669	cellular response to nutrient levels	Biological Process	IDA	PMID:31601708
GO:0032480	negative regulation of type I interferon production	Biological Process	IDA	PMID:36394357
GO:0032481	positive regulation of type I interferon production	Biological Process	IDA	PMID:17404045
GO:0034198	cellular response to amino acid starvation	Biological Process	IDA	PMID:35338845
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IDA	PMID:29769719
GO:0050868	negative regulation of T cell activation	Biological Process	IDA	PMID:38377992
GO:0071230	cellular response to amino acid stimulus	Biological Process	IDA	PMID:29769719
GO:1904262	negative regulation of TORC1 signaling	Biological Process	IDA	PMID:35338845
GO:1904263	positive regulation of TORC1 signaling	Biological Process	IDA	PMID:29769719
GO:0000070	mitotic sister chromatid segregation	Biological Process	IMP	PMID:23455478
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	Biological Process	IDA	PMID:33109719
GO:0006513	protein monoubiquitination	Biological Process	IEA	GO_REF:0000002
GO:0007094	mitotic spindle assembly checkpoint signaling	Biological Process	IMP	PMID:23455478
GO:0010507	negative regulation of autophagy	Biological Process	IMP	PMID:29769719
GO:0030307	positive regulation of cell growth	Biological Process	IMP	PMID:29769719
GO:0050870	positive regulation of T cell activation	Biological Process	IDA	PMID:33109719
GO:0051301	cell division	Biological Process	IEA	GO_REF:0000120
GO:0071233	cellular response to L-leucine	Biological Process	IMP	PMID:29769719
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005764	lysosome	Cellular Component	IDA	PMID:29769719
GO:0005737	cytoplasm	Cellular Component	IC	PMID:36394357
GO:0005827	polar microtubule	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	IBA	GO_REF:0000033
GO:0072686	mitotic spindle	Cellular Component	IBA	GO_REF:0000033
GO:0005813	centrosome	Cellular Component	IEA	GO_REF:0000044
GO:0005819	spindle	Cellular Component	IEA	GO_REF:0000044
GO:0005856	cytoskeleton	Cellular Component	IEA	GO_REF:0000043
GO:0015630	microtubule cytoskeleton	Cellular Component	IDA	GO_REF:0000052
GO:0045171	intercellular bridge	Cellular Component	IDA	GO_REF:0000052
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:17543862
GO:0071889	14-3-3 protein binding	Molecular Function	IPI	PMID:29769719
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IDA	PMID:29769719

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