KLH12

Details:

UniProt Entry: Q53G59
Gene: KLHL12
Class: Other E3 Components
Family: Adaptor
Protein length: 568
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q53G59
MGGIMAPKDI MTNTHAKSIL NSMNSLRKSN TLCDVTLRVE QKDFPAHRIV LAACSDYFCA
MFTSELSEKG KPYVDIQGLT ASTMEILLDF VYTETVHVTV ENVQELLPAA CLLQLKGVKQ
ACCEFLESQL DPSNCLGIRD FAETHNCVDL MQAAEVFSQK HFPEVVQHEE FILLSQGEVE
KLIKCDEIQV DSEEPVFEAV INWVKHAKKE REESLPNLLQ YVRMPLLTPR YITDVIDAEP
FIRCSLQCRD LVDEAKKFHL RPELRSQMQG PRTRARLGAN EVLLVVGGFG SQQSPIDVVE
KYDPKTQEWS FLPSITRKRR YVASVSLHDR IYVIGGYDGR SRLSSVECLD YTADEDGVWY
SVAPMNVRRG LAGATTLGDM IYVSGGFDGS RRHTSMERYD PNIDQWSMLG DMQTAREGAG
LVVASGVIYC LGGYDGLNIL NSVEKYDPHT GHWTNVTPMA TKRSGAGVAL LNDHIYVVGG
FDGTAHLSSV EAYNIRTDSW TTVTSMTTPR CYVGATVLRG RLYAIAGYDG NSLLSSIECY
DPIIDSWEVV TSMGTQRCDA GVCVLREK

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	568	Family	BTB-kelch protein	IPR017096	PIRSF037037
6	131	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
12	128	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	129	Domain	BTB/POZ domain	IPR000210	PF00651
33	130	Domain	BTB/POZ domain	IPR000210	SM00225
33	100	Domain	BTB/POZ domain	IPR000210	PS50097
135	237	Domain	BTB/Kelch-associated	IPR011705	SM00875
135	236	Domain	BTB/Kelch-associated	IPR011705	PF07707
267	567	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
280	482	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
281	314	Repeat	Kelch repeat type 1	IPR006652	PF01344
282	329	Repeat	Kelch repeat type 1	IPR006652	SM00612
319	366	Repeat	Kelch repeat type 1	IPR006652	PF01344
330	379	Repeat	Kelch repeat type 1	IPR006652	SM00612
368	413	Repeat	Kelch repeat type 1	IPR006652	PF01344
380	426	Repeat	Kelch repeat type 1	IPR006652	SM00612
416	459	Repeat	Kelch repeat type 1	IPR006652	PF01344
427	473	Repeat	Kelch repeat type 1	IPR006652	SM00612
463	506	Repeat	Kelch repeat type 1	IPR006652	PF01344
474	520	Repeat	Kelch repeat type 1	IPR006652	SM00612
509	554	Repeat	Kelch repeat type 1	IPR006652	PF01344
521	567	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006513	protein monoubiquitination	Biological Process	IDA	PMID:22358839
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	Biological Process	IDA	PMID:22358839
GO:0009653	anatomical structure morphogenesis	Biological Process	IEA	GO_REF:0000117
GO:0009888	tissue development	Biological Process	IEA	GO_REF:0000117
GO:0014029	neural crest formation	Biological Process	IMP	PMID:27716508
GO:0014032	neural crest cell development	Biological Process	IMP	PMID:27716508
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000120
GO:0016192	vesicle-mediated transport	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0048208	COPII vesicle coating	Biological Process	IBA	GO_REF:0000033
GO:0034451	centriolar satellite	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0030134	COPII-coated ER to Golgi transport vesicle	Cellular Component	IBA	GO_REF:0000033
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1504190
GO:0031410	cytoplasmic vesicle	Cellular Component	IEA	GO_REF:0000043
GO:0030127	COPII vesicle coat	Cellular Component	IDA	PMID:27716508
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:16189514
GO:0042802	identical protein binding	Molecular Function	IPI	PMID:16189514
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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