KCD21

Details:

UniProt Entry: Q4G0X4
Gene: KCTD21
Class: Other E3 Components
Family: Adaptor
Protein length: 260
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q4G0X4
MSDPITLNVG GKLYTTSLAT LTSFPDSMLG AMFSGKMPTK RDSQGNCFID RDGKVFRYIL
NFLRTSHLDL PEDFQEMGLL RREADFYQVQ PLIEALQEKE VELSKAEKNA MLNITLNQRV
QTVHFTVREA PQIYSLSSSS MEVFNANIFS TSCLFLKLLG SKLFYCSNGN LSSITSHLQD
PNHLTLDWVA NVEGLPEEEY TKQNLKRLWV VPANKQINSF QVFVEEVLKI ALSDGFCIDS
SHPHALDFMN NKIIRLIRYR

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	104	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
3	104	Domain	BTB/POZ domain	IPR000210	SM00225
3	103	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
3	72	Domain	BTB/POZ domain	IPR000210	PS50097
5	93	Domain	Potassium channel tetramerisation-type BTB domain	IPR003131	PF02214
107	260	Domain	BTB/POZ domain-containing protein KCTD11/21, C-terminal domain	IPR045763	PF19329

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0051260	protein homooligomerization	Biological Process	IEA	GO_REF:0000002
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0045879	negative regulation of smoothened signaling pathway	Biological Process	IDA	PMID:21472142
GO:0042802	identical protein binding	Molecular Function	IEA	GO_REF:0000117
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0042826	histone deacetylase binding	Molecular Function	IBA	GO_REF:0000033
GO:0097602	cullin family protein binding	Molecular Function	IBA	GO_REF:0000033

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