TRI60

Details:

UniProt Entry: Q495X7
Gene: TRIM60
Class: RING
Family: RING5
Protein length: 471
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q495X7
MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT FPCPVCRFCF
PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH NQFLTLFCVK DLEILCTQCS
FSTKHQKHYI CPIKKAASYH REILEGSLEP LRNNIERVEK VIILQGSKSV ELKKKVEYKR
EEINSEFEQI RLFLQNEQEM ILRQIQDEEM NILAKLNENL VELSDYVSTL KHLLREVEGK
SVQSNLELLT QAKSMHHKYQ NLKCPELFSF RLTKYGFSLP PQYSGLDRII KPFQVDVILD
LNTAHPQLLV SEDRKAVRYE RKKRNICYDP RRFYVCPAVL GSQRFSSGRH YWEVEVGNKP
KWILGVCQDC LLRNWQDQPS VLGGFWAIGR YMKSGYVASG PKTTQLLPVV KPSKIGIFLD
YELGDLSFYN MNDRSILYTF NDCFTEAVWP YFYTGTDSEP LKICSVSDSE R

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	81	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
16	56	Domain	Zinc finger, RING-type	IPR001841	SM00184
16	57	Domain	Zinc finger, RING-type	IPR001841	PS50089
31	40	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
92	133	Domain	B-box-type zinc finger	IPR000315	PS50119
92	133	Domain	B-box-type zinc finger	IPR000315	SM00336
93	133	Domain	B-box-type zinc finger	IPR000315	PF00643
277	470	Domain	B30.2/SPRY domain	IPR001870	PS50188
286	465	Domain	TRIM60, PRY/SPRY domain	IPR035786	cd15828
288	466	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
288	471	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
293	310	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
294	346	Domain	SPRY-associated	IPR006574	SM00589
297	345	Domain	SPRY-associated	IPR006574	PF13765
310	327	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
332	356	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
347	467	Domain	SPRY domain	IPR003877	SM00449
349	455	Domain	SPRY domain	IPR003877	PF00622
362	375	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
406	430	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407
436	454	Domain	Butyrophylin-like, SPRY domain	IPR003879	PR01407

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0007249	canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:10882101
GO:0038061	non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:33184450
GO:0070534	protein K63-linked ubiquitination	Biological Process	IDA	PMID:20038579
GO:0010468	regulation of gene expression	Biological Process	IBA	GO_REF:0000033
GO:0045087	innate immune response	Biological Process	IBA	GO_REF:0000033
GO:1901223	negative regulation of non-canonical NF-kappaB signal transduction	Biological Process	IDA	PMID:33184450
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32296183
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033
GO:0140082	SUMO-ubiquitin ligase activity	Molecular Function	IDA	PMID:33184450

Enzyme–Substrate Interactions ▾

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