PCGF3

Details:

UniProt Entry: Q3KNV8
Gene: PCGF3
Class: RING
Family: RING4
Protein length: 242
Database confidence: 0.75
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q3KNV8
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH
QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD
SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA
TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD
LL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
2	104	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
17	56	Domain	Zinc finger, RING-type	IPR001841	PS50089
17	55	Domain	Zinc finger, RING-type	IPR001841	SM00184
33	42	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
172	236	Domain	RAWUL domain	IPR032443	PF16207

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0060816	random inactivation of X chromosome	Biological Process	ISS	GO_REF:0000024
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000043
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0031519	PcG protein complex	Cellular Component	IEA	GO_REF:0000117
GO:0000805	X chromosome	Cellular Component	ISS	GO_REF:0000024
GO:0005654	nucleoplasm	Cellular Component	IEA	GO_REF:0000044
GO:0035102	PRC1 complex	Cellular Component	IBA	GO_REF:0000033
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:21282530
GO:0140862	histone H2AK119 ubiquitin ligase activity	Molecular Function	ISS	GO_REF:0000024

Enzyme–Substrate Interactions ▾

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