KLH38

Details:

UniProt Entry: Q2WGJ6
Gene: KLHL38
Class: Other E3 Components
Family: Adaptor
Protein length: 581
Database confidence: 0.375
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q2WGJ6
MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN VLASSSPYFR
AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA TDNVLPVMEA ASMLQFPKLF
EACSSYLQSQ LAPSNCLGMI RLSEILSCET LKKKAREVAL TSFPEVAASA DLKELCALEL
RDYLGDDGLC GEEEKVFEAL MVWIKHDLQA RKRYMQELFK QVRLQYIHPA FFHHFIANDA
LLQSSPACQI ILETAKRQMF SLCGTTVPDC KLLLHVPPRN SYQDFLILLG GRKDSQQTTR
DVLLYSKQTG QWQSLAKLPT RLYKASAITL HRSIYVLGGM AVSSGRSLVS HNVYIFSLKL
NQWRLGEPML VARYSHRSTA HKNFIFSIGG IGEGQELMGS MERYDSICNV WESMASMPVG
VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ VYHISRNSWF KMETRMIKNV CAPAVVLGER
IVIVGGYTRR ILAYDPQSNK FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS
ASFDCYDPET DTWTSQGQLP HKLFDHACLT LQCIPRTSGL P

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
3	576	Family	BTB-kelch protein	IPR017096	PIRSF037037
7	132	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
11	129	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
24	130	Domain	BTB/POZ domain	IPR000210	PF00651
34	101	Domain	BTB/POZ domain	IPR000210	PS50097
34	131	Domain	BTB/POZ domain	IPR000210	SM00225
131	229	Domain	Kelch-like protein 38, BACK domain	IPR030568	cd18476
136	236	Domain	BTB/Kelch-associated	IPR011705	PF07707
136	237	Domain	BTB/Kelch-associated	IPR011705	SM00875
279	490	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
284	570	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
285	332	Repeat	Kelch repeat type 1	IPR006652	SM00612
333	383	Repeat	Kelch repeat type 1	IPR006652	SM00612
372	418	Repeat	Kelch repeat type 1	IPR006652	PF01344
384	431	Repeat	Kelch repeat type 1	IPR006652	SM00612
480	521	Repeat	Kelch repeat type 1	IPR006652	SM00612
491	573	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
510	556	Repeat	Kelch repeat type 1	IPR006652	PF01344
522	573	Repeat	Kelch repeat type 1	IPR006652	SM00612

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:22939624
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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