KLH40

Details:

UniProt Entry: Q2TBA0
Gene: KLHL40
Class: Other E3 Components
Family: Adaptor
Protein length: 621
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q2TBA0
MALGLEQAEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVRAG EREFPCHRLV LAACSPYFRA
RFLAEPERAG ELHLEEVSPD VVAQVLHYLY TSEIALDEAS VQDLFAAAHR FQIPSIFTIC
VSFLQKRLCL SNCLAVFRLG LLLDCARLAV AARDFICAHF TLVARDADFL GLSADELIAI
ISSDGLNVEK EEAVFEAVMR WAGSGDAEAQ AERQRALPTV FESVRCRLLP RAFLESRVER
HPLVRAQPEL LRKVQMVKDA HEGRITTLRK KKKGKDGAGA KEADKGTSKA KAEEDEEAER
ILPGILNDTL RFGMFLQDLI FMISEEGAVA YDPAANECYC ASLSNQVPKN HVSLVTKENQ
VFVAGGLFYN EDNKEDPMSA YFLQFDHLDS EWLGMPPLPS PRCLFGLGEA LNSIYVVGGR
EIKDGERCLD SVMCYDRLSF KWGESDPLPY VVYGHTVLSH MDLVYVIGGK GSDRKCLNKM
CVYDPKKFEW KELAPMQTAR SLFGATVHDG RIIVAAGVTD TGLTSSAEVY SITDNKWAPF
EAFPQERSSL SLVSLVGTLY AIGGFATLET ESGELVPTEL NDIWRYNEEE KKWEGVLREI
AYAAGATFLP VRLNVLCLTK M

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	614	Family	BTB-kelch protein	IPR017096	PIRSF037037
11	131	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
18	127	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	127	Domain	BTB/POZ domain	IPR000210	PF00651
33	128	Domain	BTB/POZ domain	IPR000210	SM00225
33	98	Domain	BTB/POZ domain	IPR000210	PS50097
133	238	Domain	BTB/Kelch-associated	IPR011705	PF07707
133	239	Domain	BTB/Kelch-associated	IPR011705	SM00875
314	621	Homologous_superfamily	Kelch-type beta propeller	IPR015915	G3DSA:2.120.10.80
329	596	Homologous_superfamily	Kelch-type beta propeller	IPR015915	SSF117281
360	412	Repeat	Kelch repeat type 1	IPR006652	SM00612
413	462	Repeat	Kelch repeat type 1	IPR006652	SM00612
453	497	Repeat	Kelch repeat type 1	IPR006652	PF01344
463	510	Repeat	Kelch repeat type 1	IPR006652	SM00612
499	538	Repeat	Kelch repeat type 1	IPR006652	PF01344
511	557	Repeat	Kelch repeat type 1	IPR006652	SM00612
547	594	Repeat	Kelch repeat type 1	IPR006652	PF01344

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0031397	negative regulation of protein ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0031398	positive regulation of protein ubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0032435	negative regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0048741	skeletal muscle fiber development	Biological Process	ISS	GO_REF:0000024
GO:0098528	skeletal muscle fiber differentiation	Biological Process	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0031672	A band	Cellular Component	IBA	GO_REF:0000033
GO:0031674	I band	Cellular Component	IBA	GO_REF:0000033
GO:0031463	Cul3-RING ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:28514442
GO:1990756	ubiquitin-like ligase-substrate adaptor activity	Molecular Function	IBA	GO_REF:0000033

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