LIN41

Details:

UniProt Entry: Q2Q1W2
Gene: TRIM71
Class: RING
Family: RING8
Protein length: 868
Database confidence: 0.5
InterPro: InterPro Entry
Mode of Action: Unclassified
AlphaFold Model: Link
PDB Structures: 7qrx

Protein Sequence ▾

>Q2Q1W2
MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG AAARRLHVLP
CLHAFCRPCL EAHRLPAAGG GAAGEPLKLR CPVCDQKVVL AEAAGMDALP SSAFLLSNLL
DAVVATADEP PPKNGRAGAP AGAGGHSNHR HHAHHAHPRA SASAPPLPQA PQPPAPSRSA
PGGPAASPSA LLLRRPHGCS SCDEGNAASS RCLDCQEHLC DNCVRAHQRV RLTKDHYIER
GPPGPGAAAA AQQLGLGPPF PGPPFSILSV FPERLGFCQH HDDEVLHLYC DTCSVPICRE
CTMGRHGGHS FIYLQEALQD SRALTIQLLA DAQQGRQAIQ LSIEQAQTVA EQVEMKAKVV
QSEVKAVTAR HKKALEEREC ELLWKVEKIR QVKAKSLYLQ VEKLRQNLNK LESTISAVQQ
VLEEGRALDI LLARDRMLAQ VQELKTVRSL LQPQEDDRVM FTPPDQALYL AIKSFGFVSS
GAFAPLTKAT GDGLKRALQG KVASFTVIGY DHDGEPRLSG GDLMSAVVLG PDGNLFGAEV
SDQQNGTYVV SYRPQLEGEH LVSVTLCNQH IENSPFKVVV KSGRSYVGIG LPGLSFGSEG
DSDGKLCRPW GVSVDKEGYI IVADRSNNRI QVFKPCGAFH HKFGTLGSRP GQFDRPAGVA
CDASRRIVVA DKDNHRIQIF TFEGQFLLKF GEKGTKNGQF NYPWDVAVNS EGKILVSDTR
NHRIQLFGPD GVFLNKYGFE GALWKHFDSP RGVAFNHEGH LVVTDFNNHR LLVIHPDCQS
ARFLGSEGTG NGQFLRPQGV AVDQEGRIIV ADSRNHRVQM FESNGSFLCK FGAQGSGFGQ
MDRPSGIAIT PDGMIVVVDF GNNRILVF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
12	94	Domain	Zinc finger, RING-type	IPR001841	SM00184
12	95	Domain	Zinc finger, RING-type	IPR001841	PS50089
51	104	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
61	70	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
194	243	Domain	B-box-type zinc finger	IPR000315	SM00336
273	314	Domain	B-box-type zinc finger	IPR000315	SM00336
273	314	Domain	B-box-type zinc finger	IPR000315	PS50119
276	312	Domain	B-box-type zinc finger	IPR000315	PF00643
479	580	Repeat	Filamin/ABP280 repeat-like	IPR017868	PS50194
483	583	Repeat	Filamin/ABP280 repeat	IPR001298	SM00557
484	585	Homologous_superfamily	Immunoglobulin-like fold	IPR013783	G3DSA:2.60.40.10
486	580	Homologous_superfamily	Immunoglobulin E-set	IPR014756	SSF81296
487	577	Repeat	Filamin/ABP280 repeat-like	IPR017868	PF00630
593	636	Repeat	NHL repeat	IPR001258	PS51125
606	633	Repeat	NHL repeat	IPR001258	PF01436
637	781	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
640	683	Repeat	NHL repeat	IPR001258	PS51125
653	680	Repeat	NHL repeat	IPR001258	PF01436
687	730	Repeat	NHL repeat	IPR001258	PS51125
700	725	Repeat	NHL repeat	IPR001258	PF01436
734	777	Repeat	NHL repeat	IPR001258	PS51125
747	773	Repeat	NHL repeat	IPR001258	PF01436
781	824	Repeat	NHL repeat	IPR001258	PS51125
782	868	Homologous_superfamily	Six-bladed beta-propeller, TolB-like	IPR011042	G3DSA:2.120.10.30
794	821	Repeat	NHL repeat	IPR001258	PF01436
828	868	Repeat	NHL repeat	IPR001258	PS51125
843	868	Repeat	NHL repeat	IPR001258	PF01436

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0001843	neural tube closure	Biological Process	IEA	GO_REF:0000107
GO:0051246	regulation of protein metabolic process	Biological Process	IEA	GO_REF:0000107
GO:0060964	regulation of miRNA-mediated gene silencing	Biological Process	IEA	GO_REF:0000107
GO:2000637	positive regulation of miRNA-mediated gene silencing	Biological Process	IEA	GO_REF:0000107
GO:0010608	post-transcriptional regulation of gene expression	Biological Process	IMP	PMID:28431233
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process	ISS	GO_REF:0000024
GO:0000209	protein polyubiquitination	Biological Process	IBA	GO_REF:0000033
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process	ISS	GO_REF:0000024
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0017148	negative regulation of translation	Biological Process	IEA	GO_REF:0000117
GO:0021915	neural tube development	Biological Process	ISS	GO_REF:0000024
GO:0031047	regulatory ncRNA-mediated gene silencing	Biological Process	IEA	GO_REF:0000120
GO:0035196	miRNA processing	Biological Process	IMP	PMID:28431233
GO:0035278	miRNA-mediated gene silencing by inhibition of translation	Biological Process	ISS	GO_REF:0000024
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IBA	GO_REF:0000033
GO:0051865	protein autoubiquitination	Biological Process	ISS	GO_REF:0000024
GO:0061158	3'-UTR-mediated mRNA destabilization	Biological Process	IDA	PMID:23125361
GO:0072089	stem cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:2000177	regulation of neural precursor cell proliferation	Biological Process	ISS	GO_REF:0000024
GO:0000932	P-body	Cellular Component	ISS	GO_REF:0000024
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0003723	RNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	ISS	GO_REF:0000024
GO:0005515	protein binding	Molecular Function	IPI	PMID:23125361
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0030371	translation repressor activity	Molecular Function	IDA	PMID:23125361
GO:0035198	miRNA binding	Molecular Function	ISS	GO_REF:0000024
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000120
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IBA	GO_REF:0000033

Enzyme–Substrate Interactions ▾


Q6ZN17	LN28B	Yes	Yes	No	No	—	No	E3-specific

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