LONF2

Details:

UniProt Entry: Q1L5Z9
Gene: LONRF2
Class: RING
Family: RING9
Protein length: 754
Database confidence: 0.625
InterPro: InterPro Entry
Mode of Action: Standalone
AlphaFold Model: Link

Protein Sequence ▾

>Q1L5Z9
MSPEPVPPPP PPQCPGCDRA EPIAQRLEEG DEAFRAGDYE MAAELFRSML AGLAQPDRGL
CLRLGDALAR AGRLPEALGA FRGAARLGAL RPEELEELAG GLVRAVGLRD RPLSAENPGG
EPEAPGEGGP APEPRAPRDL LGCPRCRRLL HKPVTLPCGL TVCKRCVEPG PARPQVRRVN
VVLSGLLEKC FPAECRLRRL AGQARSLQRQ QQPEAALLRC DQALELAPDD NSLLLLRAEL
YLTMKNYEQA LQDASAACQN EPLLIKGHQV KAQALSGLGR SKEVLKEFLY CLALNPECNS
VKKEAQKVMC EVLFSATANV HENLTSSIQS RLKAQGHSHM NAQALLEEGD AGSSENSSEK
SDMLGNTNSS VLYFILGLHF EEDKKALESI LPTAPSAGLK RQFPDDVEDA PDLNAPGKIP
KKDLSLQRSP NSETEESQGL SLDVTDFECA LCMRLLFEPV TTPCGHTFCL KCLERCLDHA
PHCPLCKDKL SELLASRNFN ITVLAEELIF RYLPDELSDR KRIYDEEMSE LSNLTRDVPI
FVCAMAFPTV PCPLHVFEPR YRLMIRRCME TGTKRFGMCL SAEHAGLSEY GCMLEIKDVR
TFPDGSSVVD AIGISRFRVL SHRHRDGYNT ADIEYLEDEK VEGPEYEELA ALHDSVHQQS
VSWFASLQDR MKEQILSHFG VMPDREPEPQ SNPSGPAWSW WILAVLPLER KAQLAILGMT
SLKERLLAIR RILVIITRKM NSRQELANAR ERNN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
19	102	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
134	194	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
143	193	Domain	Zinc finger, RING-type	IPR001841	SM00184
195	311	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	G3DSA:1.25.40.10
197	230	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
202	298	Homologous_superfamily	Tetratricopeptide-like helical domain superfamily	IPR011990	SSF48452
231	264	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
265	298	Repeat	Tetratricopeptide repeat	IPR019734	SM00028
415	518	Homologous_superfamily	Zinc finger, RING/FYVE/PHD-type	IPR013083	G3DSA:3.30.40.10
449	486	Domain	Zinc finger, RING-type	IPR001841	SM00184
449	487	Domain	Zinc finger, RING-type	IPR001841	PS50089
464	473	Conserved_site	Zinc finger, RING-type, conserved site	IPR017907	PS00518
519	636	Homologous_superfamily	Lon protease, N-terminal domain superfamily	IPR046336	G3DSA:2.30.130.40
535	735	Domain	Lon protease, N-terminal domain	IPR003111	PS51787
537	733	Homologous_superfamily	PUA-like superfamily	IPR015947	SSF88697
537	735	Domain	Lon protease, N-terminal domain	IPR003111	SM00464
538	732	Domain	Lon protease, N-terminal domain	IPR003111	PF02190

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	Biological Process	IEA	GO_REF:0000107
GO:0021522	spinal cord motor neuron differentiation	Biological Process	IEA	GO_REF:0000107
GO:0031175	neuron projection development	Biological Process	IEA	GO_REF:0000107
GO:0043524	negative regulation of neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0050905	neuromuscular process	Biological Process	IEA	GO_REF:0000107
GO:0051402	neuron apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0061744	motor behavior	Biological Process	IEA	GO_REF:0000107
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0005515	protein binding	Molecular Function	IPI	PMID:32814053
GO:0043021	ribonucleoprotein complex binding	Molecular Function	IEA	GO_REF:0000107
GO:0051787	misfolded protein binding	Molecular Function	IEA	GO_REF:0000107
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000107

Enzyme–Substrate Interactions ▾

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