DDB1

Start	End	Type	Name	InterPro	Source
4	1039	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
14	355	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
75	543	Domain	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	IPR018846	PF10433
394	709	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
791	1099	Domain	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	IPR004871	PF03178
795	934	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978

GO term	Name	Ontology	Evidence	Reference
GO:0006281	DNA repair	Biological Process	IEA	GO_REF:0000043
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000117
GO:0006974	DNA damage response	Biological Process	IEA	GO_REF:0000043
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0034644	cellular response to UV	Biological Process	IEA	GO_REF:0000117
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000104
GO:0048511	rhythmic process	Biological Process	IEA	GO_REF:0000043
GO:0006915	apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0035234	ectopic germ cell programmed cell death	Biological Process	IEA	GO_REF:0000107
GO:0007056	spindle assembly involved in female meiosis	Biological Process	IDA	PMID:31492966
GO:0010498	proteasomal protein catabolic process	Biological Process	IMP	PMID:25970626
GO:0016055	Wnt signaling pathway	Biological Process	IEA	GO_REF:0000107
GO:0043066	negative regulation of apoptotic process	Biological Process	IEA	GO_REF:0000107
GO:0044725	epigenetic programming in the zygotic pronuclei	Biological Process	IDA	PMID:30111536
GO:0045732	positive regulation of protein catabolic process	Biological Process	IDA	PMID:11027288
GO:0051093	negative regulation of developmental process	Biological Process	IEA	GO_REF:0000107
GO:0051898	negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	Biological Process	IDA	PMID:31492966
GO:0060337	type I interferon-mediated signaling pathway	Biological Process	IMP	PMID:23391734
GO:0097510	base-excision repair, AP site formation via deaminated base removal	Biological Process	IDA	PMID:18973764
GO:2000242	negative regulation of reproductive process	Biological Process	IEA	GO_REF:0000107
GO:0006289	nucleotide-excision repair	Biological Process	TAS	PMID:8407967
GO:0019076	viral release from host cell	Biological Process	IMP	PMID:23137809
GO:0042752	regulation of circadian rhythm	Biological Process	IEA	GO_REF:0000107
GO:0045070	positive regulation of viral genome replication	Biological Process	IMP	PMID:23137809
GO:0045722	positive regulation of gluconeogenesis	Biological Process	ISS	GO_REF:0000024
GO:0046726	positive regulation by virus of viral protein levels in host cell	Biological Process	IMP	PMID:23137809
GO:0051702	biological process involved in interaction with symbiont	Biological Process	IDA	PMID:23137809
GO:0070914	UV-damage excision repair	Biological Process	IDA	PMID:14751237
GO:1901990	regulation of mitotic cell cycle phase transition	Biological Process	IMP	PMID:17088560
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000120
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0005730	nucleolus	Cellular Component	IDA	PMID:11673459
GO:0035861	site of double-strand break	Cellular Component	IBA	GO_REF:0000033
GO:0000781	chromosome, telomeric region	Cellular Component	HDA	PMID:19135898
GO:0005615	extracellular space	Cellular Component	HDA	PMID:22664934
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:19056867
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	Cellular Component	IDA	PMID:18794347
GO:0032991	protein-containing complex	Cellular Component	IMP	PMID:28437394
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000043
GO:0003684	damaged DNA binding	Molecular Function	IDA	PMID:22334663
GO:0005515	protein binding	Molecular Function	IPI	PMID:10777491
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IPI	PMID:14739464
GO:0044877	protein-containing complex binding	Molecular Function	IPI	PMID:11564863
GO:0071987	WD40-repeat domain binding	Molecular Function	IPI	PMID:16949367
GO:0097602	cullin family protein binding	Molecular Function	IDA	PMID:10585395
GO:0160072	ubiquitin ligase complex scaffold activity	Molecular Function	IDA	PMID:30111536

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL5172193	ChEMBL	8.49	—	—	CC(=O)Nc1cc(Nc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc(C(C)(C)C)c1
E3 Binder	CHEMBL5183717	ChEMBL	7.96	—	—	CC(=O)Nc1cc(Oc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)cc(C(C)(C)C)c1
E3 Binder	CHEMBL5201283	ChEMBL	7.85	—	—	CC(C)(C)c1cc(N)cc(Oc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)c1
E3 Binder	CHEMBL4848064	ChEMBL	9.18	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)CCCCNC(=O)COc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL5178566	ChEMBL	9.61	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)CCOCCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL4854720	ChEMBL	8.85	—	—	CNC(=O)N1N=C(c2ccc(N3CCN(C(=O)COCCOCC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)cc2)c2cc(OC)c(OC)cc2C[C@@H]1C
E3 Binder	CHEMBL5208953	ChEMBL	7.82	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5193211	ChEMBL	6.39	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NC(=O)Nc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5174754	ChEMBL	7.62	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(NCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5205527	ChEMBL	7.77	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(OC(=O)CNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5182478	ChEMBL	7.64	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(OCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5172753	ChEMBL	7.51	—	—	COc1ccc(OC)c(-n2nnc(C(=O)Nc3cc(Oc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)cc(C(C)(C)C)c3)c2C)c1
E3 Binder	CHEMBL5090015	ChEMBL	6.21	—	—	COc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL5084741	ChEMBL	7.8	—	—	Cc1c(Cl)cccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL4170596	ChEMBL	7.75	—	—	Cc1ccc(NC(=O)NCc2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)cc1Cl
E3 Binder	CHEMBL5084281	ChEMBL	9.0	—	—	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)cc1Cl
E3 Binder	CHEMBL5073414	ChEMBL	7.96	—	—	Cc1ccccc1S(=O)(=O)Nc1ccc2c(c1)C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL4648616	ChEMBL	7.52	QFC	—	N#Cc1ccc(N2CCN(Cc3ccc(COc4cccc5c4CN([C@H]4CCC(=O)NC4=O)C5=O)cc3)CC2)c(F)c1
E3 Handle	CHEMBL43452	ChEMBL	8.05	—	—	Nc1cccc2c1C(=O)N(C1CCC(=O)NC1=O)C2=O
E3 Handle	CHEMBL848	ChEMBL	6.54	—	—	Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
E3 Binder	CHEMBL5078004	ChEMBL	8.05	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccc(OC(F)(F)F)cc4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5074427	ChEMBL	7.64	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(Cl)c4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5079426	ChEMBL	8.0	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4cccc(OC(F)(F)F)c4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5078971	ChEMBL	8.52	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5069911	ChEMBL	6.47	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4C(F)(F)F)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL5094191	ChEMBL	7.82	—	—	O=C1CCC(N2C(=O)c3ccc(NS(=O)(=O)c4ccccc4OC(F)(F)F)cc3C2=O)C(=O)N1
E3 Binder	CHEMBL4642316	ChEMBL	6.06	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(Cl)cc6Cl)CC5)cc4)c3C2=O)C(=O)N1
E3 Binder	CHEMBL4644747	ChEMBL	6.49	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(F)cc6)CC5)cc4)c3C2=O)C(=O)N1
E3 Binder	CHEMBL4645564	ChEMBL	6.3	—	—	O=C1CCC(N2C(=O)c3cccc(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)c3C2=O)C(=O)N1
E3 Handle	CHEMBL468	ChEMBL	7.44	—	—	O=C1CCC(N2C(=O)c3ccccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645905	ChEMBL	6.71	—	—	O=C1CCC(N2Cc3c(NCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4645677	ChEMBL	7.26	—	—	O=C1CCC(N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4742712	ChEMBL	6.08	—	—	O=C1CCC(N2Cc3cc(CNC(=O)C(F)(F)c4ccc(Cl)cc4)ccc3C2=O)C(=O)N1
E3 Binder	CHEMBL4647587	ChEMBL	7.43	—	—	O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCN(c6ccc(F)cc6F)CC5)cc4)cccc3C2=O)C(=O)N1

DDB1

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Small Molecule Interactions ▾