ZBTB6

Details:

UniProt Entry: Q15916
Gene: ZBTB6
Class: RING
Family: RING6
Protein length: 424
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: Complex
AlphaFold Model: Link

Protein Sequence ▾

>Q15916
MAAESDVLHF QFEQQGDVVL QKMNLLRQQN LFCDVSIYIN DTEFQGHKVI LAACSTFMRD
QFLLTQSKHV RITILQSAEV GRKLLLSCYT GALEVKRKEL LKYLTAASYL QMVHIVEKCT
EALSKYLEID LSMKNNNQHT DLCQSSDPDV KNEDENSDKD CEIIEISEDS PVNIDFHVKE
EESNALQSTV ESLTSERKEM KSPELSTVDI GFKDNEICIL HVESISTAGV ENGQFSQPCT
SSKASMYFSE TQHSLINSTV ESRVAEVPGN QDQGLFCENT EGSYGTVSEI QNLEEGYSLR
HQCPRCPRGF LHVENYLRHL KMHKLFLCLQ CGKTFTQKKN LNRHIRGHMG IRPFQCTVCL
KTFTAKSTLQ DHLNIHSGDR PYKCHCCDMD FKHKSALKKH LTSVHGRSSG EKLSRPDLKR
QSLL

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
7	159	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
9	124	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695
23	125	Domain	BTB/POZ domain	IPR000210	PF00651
33	97	Domain	BTB/POZ domain	IPR000210	PS50097
33	127	Domain	BTB/POZ domain	IPR000210	SM00225
301	323	Domain	Zinc finger C2H2-type	IPR013087	PS50157
301	323	Domain	Zinc finger C2H2-type	IPR013087	SM00355
310	363	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
326	353	Domain	Zinc finger C2H2-type	IPR013087	PS50157
326	348	Domain	Zinc finger C2H2-type	IPR013087	SM00355
327	348	Domain	Zinc finger C2H2-type	IPR013087	PF00096
328	348	Domain	Zinc finger C2H2-type	IPR013087	PS00028
348	400	Homologous_superfamily	Zinc finger C2H2 superfamily	IPR036236	SSF57667
354	376	Domain	Zinc finger C2H2-type	IPR013087	SM00355
354	381	Domain	Zinc finger C2H2-type	IPR013087	PS50157
354	376	Domain	Zinc finger C2H2-type	IPR013087	PF00096
356	376	Domain	Zinc finger C2H2-type	IPR013087	PS00028
382	405	Domain	Zinc finger C2H2-type	IPR013087	PS50157
382	405	Domain	Zinc finger C2H2-type	IPR013087	SM00355
384	405	Domain	Zinc finger C2H2-type	IPR013087	PS00028

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000122	negative regulation of transcription by RNA polymerase II	Biological Process	IBA	GO_REF:0000033
GO:0001817	regulation of cytokine production	Biological Process	IBA	GO_REF:0000033
GO:0002682	regulation of immune system process	Biological Process	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IBA	GO_REF:0000033
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000120
GO:0005739	mitochondrion	Cellular Component	IDA	GO_REF:0000052
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	Molecular Function	IBA	GO_REF:0000033
GO:0003677	DNA binding	Molecular Function	IEA	GO_REF:0000120
GO:0005515	protein binding	Molecular Function	IPI	PMID:25416956
GO:0008270	zinc ion binding	Molecular Function	IEA	GO_REF:0000043
GO:0046872	metal ion binding	Molecular Function	IEA	GO_REF:0000043

Enzyme–Substrate Interactions ▾

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