UB2V2

Details:

UniProt Entry: Q15819
Gene: UBE2V2
Class: Other E3 Components
Family: E2
Protein length: 145
Database confidence: 0.125
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q15819
MAVSTGVKVP RNFRLLEELE EGQKGVGDGT VSWGLEDDED MTLTRWTGMI IGPPRTNYEN
RIYSLKVECG PKYPEAPPSV RFVTKINMNG INNSSGMVDA RSIPVLAKWQ NSYSIKVVLQ
ELRRLMMSKE NMKLPQPPEG QTYNN

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	145	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	G3DSA:3.10.110.10
7	144	Homologous_superfamily	Ubiquitin-conjugating enzyme/RWD-like	IPR016135	SSF54495
10	145	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PS50127
31	133	Domain	Ubiquitin-conjugating enzyme E2	IPR000608	PF00179

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0042275	error-free postreplication DNA repair	Biological Process	IEA	GO_REF:0000107
GO:0006282	regulation of DNA repair	Biological Process	IEA	GO_REF:0000117
GO:1902523	positive regulation of protein K63-linked ubiquitination	Biological Process	IEA	GO_REF:0000117
GO:0000209	protein polyubiquitination	Biological Process	TAS	PMID:10089880
GO:0000729	DNA double-strand break processing	Biological Process	IMP	PMID:17349954
GO:0006301	postreplication repair	Biological Process	IBA	GO_REF:0000033
GO:0016567	protein ubiquitination	Biological Process	TAS	PMID:16129784
GO:0070534	protein K63-linked ubiquitination	Biological Process	IBA	GO_REF:0000033
GO:2000781	positive regulation of double-strand break repair	Biological Process	IDA	PMID:16129784
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0031372	UBC13-MMS2 complex	Cellular Component	IEA	GO_REF:0000117
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005737	cytoplasm	Cellular Component	TAS	PMID:16129784
GO:0070062	extracellular exosome	Cellular Component	HDA	PMID:23533145
GO:0031371	ubiquitin conjugating enzyme complex	Cellular Component	IBA	GO_REF:0000033
GO:0005515	protein binding	Molecular Function	IPI	PMID:11473255

Data Usage Statement and License Agreement

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The E3 Ligome database, including all associated data, metadata, and documentation, is the intellectual property of Goethe University (PROXIDRUGs consortium) under the InnoDATA project.
The contents of this Database are protected under applicable copyright and database protection laws.

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Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta, A., Cristiani, A., Nikte, S.V. et al. Multi-scale classification decodes the complexity of the human E3 ligome. Nat Commun 16, 11382 (2025).

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For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.