HERC1

>Q15751
MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK
YHDKGKVKQQ QHSPESSSGS ADVHSVSERP RSSTDALIEM GVRTGLSLLF ALLRQSWMMP
VSGPGLSLCN DVIHTAIEVV SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD
TLGRRLASEL LLGLAAQRGS LRYLLEWIEM ALGASAVVHT MEKGKLLSSQ EGMISFDCFM
TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY SRTCASPDSI
QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP SFSDAQTIEA GQYCTFVIST
DGSVRACGKG SYGRLGLGDS NNQSTLKKLT FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF
SWGDGDYGKL GHGNSSTQKY PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF
GRLGHGDSNS RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE ATALRPKLIE
ELAATRIVDV SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG NSTGPITKPK KVSGLDGIAI
QQISAGTSHS LAWTALPRDR QVVAWHRPYC VDLEESTFSH LRSFLERYCD KINSEIPPLP
FPSSREHHSF LKLCLKLLSN HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE
VVIETLSVGA TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR NLGFYTDQAF
GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC HINNISENSS SVALLHKHLQ
LLLPHATDIY SRSANLLKES PWNGSVGEKL RDVIYVSAAG SMLCQIVNSL LLLPVSVARP
LLSYLLDLLP PLDCLNRLLP AADLLEDQEL QWPLHGGPEL IDPAGLPLPQ PAQSWVWLVD
LERTIALLIG RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD SATLSNESLL
DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KHLSEVYRCV YKVRSRLLAC KNLELIQTRS
SSRDRWISEN QDSADVDPQE HSFTRTIDEE AEMEEQAERD REEGHPEPED EEEEREHEVM
TAGKIFQCFL SAREVARSRD RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA
ACNSVIHRCA LLILGVSPVI DELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH
TSPNYRLIKS RSESDLSQPE SDEEGYALSG RRNVDLDLAA SHRKRGPMHS QLESLSDSWA
RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS GDVGNAPGFK EPEESMSTSP
QASIIAMEQQ QLRAELRLEA LHQILVLLSG MEEKGSISLA GSRLSSGFQS STLLTSVRLQ
FLAGCFGLGT VGHTGGKGES GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL
QANKHHIEAQ QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK NLLSQTGVLH
MASFGEGEQE DGEEEEKKVD SSGETEKKDF RAALRKQHAA ELHLGDFLVF LRRVVSSKAI
QSKMASPKWT EVLLNIASQK CSSGIPLVGN LRTRLLALHV LEAVLPACES GVEDDQMAQI
VERLFSLLSD CMWETPIAQA KHAIQIKEKE QEIKLQKQGE LEEEDENLPI QEVSFDPEKA
QCCLVENGQI LTHGSGGKGY GLASTGVTSG CYQWKFYIVK ENRGNEGTCV GVSRWPVHDF
NHRTTSDMWL YRAYSGNLYH NGEQTLTLSS FTQGDFITCV LDMEARTISF GKNGEEPKLA
FEDVDAAELY PCVMFYSSNP GEKVKICDMQ MRGTPRDLLP GDPICSPVAA VLAEATIQLI
RILHRTDRWT YCINKKMMER LHKIKICIKE SGQKLKKSRS VQSREENEMR EEKESKEEEK
GKHTRHGLAD LSELQLRTLC IEVWPVLAVI GGVDAGLRVG GRCVHKQTGR HATLLGVVKE
GSTSAKVQWD EAEITISFPT FWSPSDTPLY NLEPCEPLPF DVARFRGLTA SVLLDLTYLT
GVHEDMGKQS TKRHEKKHRH ESEEKGDVEQ KPESESALDM RTGLTSDDVK SQSTTSSKSE
NEIASFSLDP TLPSVESQHQ ITEGKRKNHE HMSKNHDVAQ SEIRAVQLSY LYLGAMKSLS
ALLGCSKYAE LLLIPKVLAE NGHNSDCASS PVVHEDVEMR AALQFLMRHM VKRAVMRSPI
KRALGLADLE RAQAMIYKLV VHGLLEDQFG GKIKQEIDQQ AEESDPAQQA QTPVTTSPSA
SSTTSFMSSS LEDTTTATTP VTDTETVPAS ESPGVMPLSL LRQMFSSYPT TTVLPTRRAQ
TPPISSLPTS PSDEVGRRQS LTSPDSQSAR PANRTALSDP SSRLSTSPPP PAIAVPLLEM
GFSLRQIAKA MEATGARGEA DAQNITVLAM WMIEHPGHED EEEPQSGSTA DSRPGAAVLG
SGGKSNDPCY LQSPGDIPSA DAAEMEEGFS ESPDNLDHTE NAASGSGPSA RGRSAVTRRH
KFDLAARTLL ARAAGLYRSV QAHRNQSRRE GISLQQDPGA LYDFNLDEEL EIDLDDEAME
AMFGQDLTSD NDILGMWIPE VLDWPTWHVC ESEDREEVVV CELCECSVVS FNQHMKRNHP
GCGRSANRQG YRSNGSYVDG WFGGECGSGN PYYLLCGTCR EKYLAMKTKS KSTSSERYKG
QAPDLIGKQD SVYEEDWDML DVDEDEKLTG EEEFELLAGP LGLNDRRIVP EPVQFPDSDP
LGASVAMVTA TNSMEETLMQ IGCHGSVEKS SSGRITLGEQ AAALANPHDR VVALRRVTAA
AQVLLARTMV MRALSLLSVS GSSCSLAAGL ESLGLTDIRT LVRLMCLAAA GRAGLSTSPS
AMASTSERSR GGHSKANKPI SCLAYLSTAV GCLASNAPSA AKLLVQLCTQ NLISAATGVN
LTTVDDSIQR KFLPSFLRGI AEENKLVTSP NFVVTQALVA LLADKGAKLR PNYDKSEVEK
KGPLELANAL AACCLSSRLS SQHRQWAAQQ LVRTLAAHDR DNQTTLQTLA DMGGDLRKCS
FIKLEAHQNR VMTCVWCNKK GLLATSGNDG TIRVWNVTKK QYSLQQTCVF NRLEGDAEES
LGSPSDPSFS PVSWSISGKY LAGALEKMVN IWQVNGGKGL VDIQPHWVSA LAWPEEGPAT
AWSGESPELL LVGRMDGSLG LIEVVDVSTM HRRELEHCYR KDVSVTCIAW FSEDRPFAVG
YFDGKLLLGT KEPLEKGGIV LIDAHKDTLI SMKWDPTGHI LMTCAKEDSV KLWGSISGCW
CCLHSLCHPS IVNGIAWCRL PGKGSKLQLL MATGCQSGLV CVWRIPQDTT QTNVTSAEGW
WEQESNCQDG YRKSSGAKCV YQLRGHITPV RTVAFSSDGL ALVSGGLGGL MNIWSLRDGS
VLQTVVIGSG AIQTTVWIPE VGVAACSNRS KDVLVVNCTA EWAAANHVLA TCRTALKQQG
VLGLNMAPCM RAFLERLPMM LQEQYAYEKP HVVCGDQLVH SPYMQCLASL AVGLHLDQLL
CNPPVPPHHQ NCLPDPASWN PNEWAWLECF STTIKAAEAL TNGAQFPESF TVPDLEPVPE
DELVFLMDNS KWINGMDEQI MSWATSRPED WHLGGKCDVY LWGAGRHGQL AEAGRNVMVP
AAAPSFSQAQ QVICGQNCTF VIQANGTVLA CGEGSYGRLG QGNSDDLHVL TVISALQGFV
VTQLVTSCGS DGHSMALTES GEVFSWGDGD YGKLGHGNSD RQRRPRQIEA LQGEEVVQMS
CGFKHSAVVT SDGKLFTFGN GDYGRLGLGN TSNKKLPERV TALEGYQIGQ VACGLNHTLA
VSADGSMVWA FGDGDYGKLG LGNSTAKSSP QKIDVLCGIG IKKVACGTQF SVALTKDGHV
YTFGQDRLIG LPEGRARNHN RPQQIPVLAG VIIEDVAVGA EHTLALASNG DVYAWGSNSE
GQLGLGHTNH VREPTLVTGL QGKNVRQISA GRCHSAAWTA PPVPPRAPGV SVPLQLGLPD
TVPPQYGALR EVSIHTVRAR LRLLYHFSDL MYSSWRLLNL SPNNQNSTSH YNAGTWGIVQ
GQLRPLLAPR VYTLPMVRSI GKTMVQGKNY GPQITVKRIS TRGRKCKPIF VQIARQVVKL
NASDLRLPSR AWKVKLVGEG ADDAGGVFDD TITEMCQELE TGIVDLLIPS PNATAEVGYN
RDRFLFNPSA CLDEHLMQFK FLGILMGVAI RTKKPLDLHL APLVWKQLCC VPLTLEDLEE
VDLLYVQTLN SILHIEDSGI TEESFHEMIP LDSFVGQSAD GKMVPIIPGG NSIPLTFSNR
KEYVERAIEY RLHEMDRQVA AVREGMSWIV PVPLLSLLTA KQLEQMVCGM PEISVEVLKK
VVRYREVDEQ HQLVQWFWHT LEEFSNEERV LFMRFVSGRS RLPANTADIS QRFQIMKVDR
PYDSLPTSQT CFFQLRLPPY SSQLVMAERL RYAINNCRSI DMDNYMLSRN VDNAEGSDTD
Y

The same domains may appear in multiple rows, following InterPro convention.

Start	End	Type	Name	InterPro	Source
368	734	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
371	735	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
372	421	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
422	476	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
476	526	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
477	529	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
516	526	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
529	576	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
530	579	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
566	576	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
581	632	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
583	629	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
633	683	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
633	680	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
683	732	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
684	736	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
2002	2193	Domain	B30.2/SPRY domain	IPR001870	PS50188
2026	2208	Homologous_superfamily	Concanavalin A-like lectin/glucanase domain superfamily	IPR013320	SSF49899
2032	2189	Domain	HERC1, SPRY domain	IPR035768	cd12881
2034	2192	Homologous_superfamily	B30.2/SPRY domain superfamily	IPR043136	G3DSA:2.60.120.920
2069	2190	Domain	SPRY domain	IPR003877	SM00449
2075	2186	Domain	SPRY domain	IPR003877	PF00622
3414	3819	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
3417	3456	Repeat	WD40 repeat	IPR001680	SM00320
3423	3456	Repeat	WD40 repeat	IPR001680	PF00400
3424	3465	Repeat	WD40 repeat	IPR001680	PS50082
3425	3709	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
3443	3457	Conserved_site	WD40 repeat, conserved site	IPR019775	PS00678
3572	3610	Repeat	WD40 repeat	IPR001680	SM00320
3615	3654	Repeat	WD40 repeat	IPR001680	SM00320
3622	3653	Repeat	WD40 repeat	IPR001680	PS50082
3659	3704	Repeat	WD40 repeat	IPR001680	SM00320
3690	3818	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
3736	3775	Repeat	WD40 repeat	IPR001680	SM00320
3738	3774	Repeat	WD40 repeat	IPR001680	PF00400
3743	3784	Repeat	WD40 repeat	IPR001680	PS50082
3994	4361	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	SSF50985
3996	4360	Homologous_superfamily	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	IPR009091	G3DSA:2.130.10.30
3997	4045	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
3998	4014	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
4046	4100	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4100	4149	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4101	4152	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4139	4149	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
4139	4155	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
4152	4201	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4153	4204	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4155	4169	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
4191	4201	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS00626
4206	4257	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4208	4254	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4247	4265	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
4257	4306	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4258	4309	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4305	4326	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PR00633
4309	4357	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PF00415
4310	4361	Repeat	Regulator of chromosome condensation, RCC1	IPR000408	PS50012
4473	4841	Domain	HECT domain	IPR000569	cd00078
4489	4837	Homologous_superfamily	HECT, E3 ligase catalytic domain	IPR035983	SSF56204
4499	4848	Domain	HECT domain	IPR000569	SM00119
4501	4848	Domain	HECT domain	IPR000569	PS50237
4563	4840	Domain	HECT domain	IPR000569	PF00632

GO term	Name	Ontology	Evidence	Reference
GO:0006914	autophagy	Biological Process	IEA	GO_REF:0000107
GO:0007420	brain development	Biological Process	IEA	GO_REF:0000107
GO:0010467	gene expression	Biological Process	IEA	GO_REF:0000107
GO:0010507	negative regulation of autophagy	Biological Process	IEA	GO_REF:0000107
GO:0021702	cerebellar Purkinje cell differentiation	Biological Process	IEA	GO_REF:0000107
GO:0022038	corpus callosum development	Biological Process	IEA	GO_REF:0000107
GO:0030282	bone mineralization	Biological Process	IEA	GO_REF:0000107
GO:0031175	neuron projection development	Biological Process	IEA	GO_REF:0000107
GO:0046849	bone remodeling	Biological Process	IEA	GO_REF:0000107
GO:0050885	neuromuscular process controlling balance	Biological Process	IEA	GO_REF:0000107
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000043
GO:0005794	Golgi apparatus	Cellular Component	IEA	GO_REF:0000120
GO:0005829	cytosol	Cellular Component	IEA	GO_REF:0000044
GO:0016020	membrane	Cellular Component	IEA	GO_REF:0000120
GO:0004842	ubiquitin-protein transferase activity	Molecular Function	IEA	GO_REF:0000002
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	IEA	GO_REF:0000043
GO:0016740	transferase activity	Molecular Function	IEA	GO_REF:0000043
GO:0061630	ubiquitin protein ligase activity	Molecular Function	IEA	GO_REF:0000003

HERC1

Details:

Protein Sequence ▾

Domain Architecture (From InterPro) ▾

Protein functions ▾

Enzyme–Substrate Interactions ▾