SF3B3

Details:

UniProt Entry: Q15393
Gene: SF3B3
Class: Other E3 Components
Family: Adaptor
Protein length: 1217
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q15393
MFLYNLTLQR ATGISFAIHG NFSGTKQQEI VVSRGKILEL LRPDPNTGKV HTLLTVEVFG
VIRSLMAFRL TGGTKDYIVV GSDSGRIVIL EYQPSKNMFE KIHQETFGKS GCRRIVPGQF
LAVDPKGRAV MISAIEKQKL VYILNRDAAA RLTISSPLEA HKANTLVYHV VGVDVGFENP
MFACLEMDYE EADNDPTGEA AANTQQTLTF YELDLGLNHV VRKYSEPLEE HGNFLITVPG
GSDGPSGVLI CSENYITYKN FGDQPDIRCP IPRRRNDLDD PERGMIFVCS ATHKTKSMFF
FLAQTEQGDI FKITLETDED MVTEIRLKYF DTVPVAAAMC VLKTGFLFVA SEFGNHYLYQ
IAHLGDDDEE PEFSSAMPLE EGDTFFFQPR PLKNLVLVDE LDSLSPILFC QIADLANEDT
PQLYVACGRG PRSSLRVLRH GLEVSEMAVS ELPGNPNAVW TVRRHIEDEF DAYIIVSFVN
ATLVLSIGET VEEVTDSGFL GTTPTLSCSL LGDDALVQVY PDGIRHIRAD KRVNEWKTPG
KKTIVKCAVN QRQVVIALTG GELVYFEMDP SGQLNEYTER KEMSADVVCM SLANVPPGEQ
RSRFLAVGLV DNTVRIISLD PSDCLQPLSM QALPAQPESL CIVEMGGTEK QDELGERGSI
GFLYLNIGLQ NGVLLRTVLD PVTGDLSDTR TRYLGSRPVK LFRVRMQGQE AVLAMSSRSW
LSYSYQSRFH LTPLSYETLE FASGFASEQC PEGIVAISTN TLRILALEKL GAVFNQVAFP
LQYTPRKFVI HPESNNLIII ETDHNAYTEA TKAQRKQQMA EEMVEAAGED ERELAAEMAA
AFLNENLPES IFGAPKAGNG QWASVIRVMN PIQGNTLDLV QLEQNEAAFS VAVCRFSNTG
EDWYVLVGVA KDLILNPRSV AGGFVYTYKL VNNGEKLEFL HKTPVEEVPA AIAPFQGRVL
IGVGKLLRVY DLGKKKLLRK CENKHIANYI SGIQTIGHRV IVSDVQESFI WVRYKRNENQ
LIIFADDTYP RWVTTASLLD YDTVAGADKF GNICVVRLPP NTNDEVDEDP TGNKALWDRG
LLNGASQKAE VIMNYHVGET VLSLQKTTLI PGGSESLVYT TLSGGIGILV PFTSHEDHDF
FQHVEMHLRS EHPPLCGRDH LSFRSYYFPV KNVIDGDLCE QFNSMEPNKQ KNVSEELDRT
PPEVSKKLED IRTRYAF

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
4	1128	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
13	403	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
76	592	Domain	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	IPR018846	PF10433
442	772	Homologous_superfamily	WD40/YVTN repeat-like-containing domain superfamily	IPR015943	G3DSA:2.130.10.10
543	1061	Homologous_superfamily	WD40-repeat-containing domain superfamily	IPR036322	SSF50978
863	1183	Domain	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	IPR004871	PF03178

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0000375	RNA splicing, via transesterification reactions	Biological Process	TAS	PMID:10490618
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IBA	GO_REF:0000033
GO:0006282	regulation of DNA repair	Biological Process	NAS	PMID:11564863
GO:0006397	mRNA processing	Biological Process	IEA	GO_REF:0000043
GO:0008380	RNA splicing	Biological Process	IEA	GO_REF:0000043
GO:0042177	negative regulation of protein catabolic process	Biological Process	IDA	PMID:23951410
GO:0043484	regulation of RNA splicing	Biological Process	NAS	PMID:11564863
GO:0045893	positive regulation of DNA-templated transcription	Biological Process	NAS	PMID:18206972
GO:1903241	U2-type prespliceosome assembly	Biological Process	NAS	PMID:31744343
GO:0005634	nucleus	Cellular Component	IBA	GO_REF:0000033
GO:0005654	nucleoplasm	Cellular Component	IDA	GO_REF:0000052
GO:0005730	nucleolus	Cellular Component	IDA	GO_REF:0000052
GO:0000124	SAGA complex	Cellular Component	NAS	PMID:19114550
GO:0005681	spliceosomal complex	Cellular Component	IEA	GO_REF:0000043
GO:0005684	U2-type spliceosomal complex	Cellular Component	IPI	PMID:27720643
GO:0005686	U2 snRNP	Cellular Component	IBA	GO_REF:0000033
GO:0005689	U12-type spliceosomal complex	Cellular Component	IDA	PMID:15146077
GO:0071005	U2-type precatalytic spliceosome	Cellular Component	IDA	PMID:28781166
GO:0071013	catalytic step 2 spliceosome	Cellular Component	IDA	PMID:11991638
GO:0003676	nucleic acid binding	Molecular Function	IEA	GO_REF:0000002
GO:0005515	protein binding	Molecular Function	IPI	PMID:17332742
GO:0030620	U2 snRNA binding	Molecular Function	IBA	GO_REF:0000033
GO:0044877	protein-containing complex binding	Molecular Function	IPI	PMID:11564863

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