ELOC

Details:

UniProt Entry: Q15369
Gene: ELOC
Class: Other E3 Components
Family: Adaptor
Protein length: 112
Database confidence: 0.25
InterPro: InterPro Entry
Mode of Action: unknown
AlphaFold Model: Link

Protein Sequence ▾

>Q15369
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV
NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC

Domain Architecture (From InterPro) ▾

Start	End	Type	Name	InterPro	Source
1	112	Family	Elongin-C	IPR039948	PTHR20648
16	112	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	G3DSA:3.30.710.10
16	112	Family	S-phase kinase-associated protein 1-like	IPR001232	SM00512
18	80	Domain	SKP1 component, POZ domain	IPR016073	PF03931
18	112	Homologous_superfamily	SKP1/BTB/POZ domain superfamily	IPR011333	SSF54695

Protein functions ▾

GO term	Name	Ontology	Evidence	Reference
GO:0006511	ubiquitin-dependent protein catabolic process	Biological Process	IEA	GO_REF:0000002
GO:0006357	regulation of transcription by RNA polymerase II	Biological Process	TAS	PMID:7660129
GO:0006367	transcription initiation at RNA polymerase II promoter	Biological Process	IDA	PMID:7660122
GO:0016567	protein ubiquitination	Biological Process	IEA	GO_REF:0000041
GO:0140958	target-directed miRNA degradation	Biological Process	IMP	PMID:33184237
GO:0005634	nucleus	Cellular Component	IEA	GO_REF:0000044
GO:0005654	nucleoplasm	Cellular Component	TAS	Reactome:R-HSA-112379
GO:0005737	cytoplasm	Cellular Component	IEA	GO_REF:0000117
GO:0005829	cytosol	Cellular Component	TAS	Reactome:R-HSA-1234159
GO:0000151	ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000117
GO:0031462	Cul2-RING ubiquitin ligase complex	Cellular Component	ISS	GO_REF:0000024
GO:0031466	Cul5-RING ubiquitin ligase complex	Cellular Component	IEA	GO_REF:0000107
GO:0070449	elongin complex	Cellular Component	IBA	GO_REF:0000033
GO:0001222	transcription corepressor binding	Molecular Function	IPI	PMID:7660122
GO:0005515	protein binding	Molecular Function	IPI	PMID:10205047
GO:0030674	protein-macromolecule adaptor activity	Molecular Function	IBA	GO_REF:0000033

Small Molecule Interactions ▾

Type	ChEMBL Compound ID	Source	pChEMBL	PDB Compound ID	PDB Codes	SMILES
E3 Binder	CHEMBL4228950	ChEMBL	7.01	9BN	—	CC(=O)C1(C(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1
E3 Binder	CHEMBL5176485	ChEMBL	6.4	—	—	CC(=O)N1c2ccc(-c3ccc(C(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N4C[C@H](O)C[C@@H]4C(=O)NCc4ccc(-c5scnc5C)cc4)C(C)(C)C)cc3)cc2[C@H](Nc2ccc(Cl)cc2)C[C@@H]1C
E3 Binder	CHEMBL4228624	ChEMBL	6.86	9BK	—	CC(=O)NC1(C(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)CC1
E3 Binder	CHEMBL4227864	ChEMBL	6.36	9B5	—	CC(=O)N[C@@H](C)C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Binder	CHEMBL4228750	ChEMBL	6.12	DV5	—	CC(=O)N[C@@H](C)C(=S)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1
E3 Handle	CHEMBL3344081	ChEMBL	6.97	3JF	—	CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL4228328	ChEMBL	6.46	—	—	CCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(-c2scnc2C)cc1)C(C)(C)C
E3 Binder	CHEMBL4229225	ChEMBL	6.11	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(C)(C)F)C(C)(C)C)cc1
E3 Binder	CHEMBL4225199	ChEMBL	6.7	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(Cl)(Cl)Cl)C(C)(C)C)cc1
E3 Binder	CHEMBL4228963	ChEMBL	6.57	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C)cc1
E3 Handle	CHEMBL4225537	ChEMBL	7.28	6Z3	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(C#N)CC2)C(C)(C)C)cc1
E3 Handle	CHEMBL4225470	ChEMBL	7.8	4YY	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4228692	ChEMBL	6.43	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(F)CC2)[C@@H](C)O)cc1
E3 Binder	CHEMBL4224868	ChEMBL	6.3	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CC(=O)C2)C(C)(C)C)cc1
E3 Binder	CHEMBL4227893	ChEMBL	6.88	9BW	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4229211	ChEMBL	6.68	9BH	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2CCC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4225714	ChEMBL	6.64	9B8	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2COC2)C(C)(C)C)cc1
E3 Binder	CHEMBL4225145	ChEMBL	6.35	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CC(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL4225856	ChEMBL	6.98	9BT	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CO)C(C)(C)C)cc1
E3 Binder	CHEMBL3260851	ChEMBL	6.05	TG0	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)c2cccc(N)c2C)cc1
E3 Binder	CHEMBL5196036	ChEMBL	6.54	—	—	Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@@H](O)C[C@H]2C(=O)NCc2ccc(-c3scnc3C)cc2)C(C)(C)C)C(C)(C)C)cc1
E3 Binder	CHEMBL4241500	ChEMBL	8.17	F7B	—	O=C1CCSc2ccc(Cl)cc21
E3 Binder	CHEMBL4244103	ChEMBL	8.3	F4K	—	OCc1ccc(-n2cccc2)cc1

Data Usage Statement and License Agreement

Ownership and Copyright

The Database, including all associated datasets, metadata, and documentation, is the intellectual property of the PROXIDRUGs consortium and the InnoDATA project.
The content of the Database is protected under applicable copyright and database protection laws.

Permitted Use

The Database is provided for research, academic, and non-commercial purposes only, unless explicitly stated otherwise.
Users are permitted to:
- Access, download, and use the data.
- Modify or build upon the data for academic, educational, or scientific purposes.
- Share derived datasets, analyses, or visualizations with proper citation and explicit acknowledgment of “The Human E3 Ligome” project.

Prohibited Use

Use the Database or any derivative works for commercial purposes without prior written consent from the PROXIDRUGs consortia (InnoDATA PIs).
Redistribute or republish the Database (or substantial parts of it) without proper credit and adherence to the license terms.
Misrepresent the data, alter metadata to mislead, or use it in a way that violates ethical or scientific standards.

Licensing

Unless otherwise stated, the Database is licensed under the Creative Commons Attribution 4.0 International License (CC BY 4.0).
This license allows redistribution and adaptation, provided appropriate credit is given.
Contributions (e.g., data corrections, additions, or scripts) can be made through merge requests on GitLab.
Contributors must agree to license their contributions under the same CC BY 4.0 license.

Citation Requirements

If you use or refer to the Database in your publications, reports, or presentations, you must cite the paper: Dutta et al. (2025, preprint)

Contact and Support

For inquiries, permissions, or support regarding the Database, please contact: Dr. Ramachandra M. Bhaskara, Goethe University Frankfurt.
Email: bhaskara@med.uni-frankfurt.de.
Website maintained by Alberto Cristiani, Arghya Dutta, and Siddhanta V. Nikte.